A modified Delphi panel to establish a threshold of meaningful progression on MDS-UPDRS Part III
Objective: To establish a threshold for meaningful progression on MDS-UPDRS Part III in an early-stage Parkinson's disease (PD) population (Hoehn & Yahr [H&Y] Stage I–II)…MIBG uptakes in the major salivary glands among Lewy body disease using a semi-automatic quantitative method
Objective: The purpose of the study is to analyze 123I-metaiodobenzhylguanidine (MIBG) uptakes in the submandibular and parotid glands in patient with Lewy body disease (LBD)…Subthalamic tremor-related oscillatory neurons play a role in the generation of Parkinson’s tremor
Objective: To explore whether subthalamic tremor-related oscillatory neurons is involved in the generation of Parkinson’s tremor. Background: Both the basal ganglia and cerebello-thalamo-cortical circuits appear…Nicotine and influences on hyperkinetic movement disorders
Objective: We describe hyperkinetic movement disorders with a variable response to smoking and nicotine and review clinical and pre-clinical evidence regarding the role of smoking,…A brainstem-oriented PET/NMR method in Parkinson’s disease
Objective: To create a voxel-based method, oriented to the brainstem and allowing the detection of Parkinson’s disease (PD) and the study of the altered connectivity…Beyond the subthalamic nucleus: tractography patterns of Magnetic Resonance-guided Focused Ultrasound subthalamotomy
Objective: To identify subthalamic clusters that predict maximum improvement in bradykinesia, rigidity and tremor. To map-out the cortical fingerprint, which predict maximum efficacy. Background: Subthalamotomy…Automated scoring of REM sleep without atonia using the open-source software RBDtector
Objective: To facilitate quantification of REM sleep without atonia (RSWA) and thereby identify patients with rapid eye movement (REM) sleep behaviour disorder (RBD). Background: RBD…Neurovascular and immune determinants of selective vulnerability of dopaminergic neurons in Parkinson’s Disease
Objective: We aimed to investigate the contribution of glial cells activation and immune cells infiltration in the selective vulnerability of dopaminergic neurons within the midbrain…Focused Ultrasound Subthalamotomy in Parkinson’s Disease: Lesion Topography and Motor Improvement.
Objective: To describe the topography of unilateral focused ultrasound (FUS) subthalamotomy in Parkinson’s disease (PD), and define correlations between lesion size/location and improvement of cardinal…Improving the design of clinical trials in early-stage Parkinson’s disease by using the estimand framework
Objective: To show how the estimand framework can be used to improve design of clinical trials testing treatments in early-stage Parkinson’s disease (PD). Background: The…
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