MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

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  • MDS Virtual Congress 2021

    Influence of onset of motor fluctuations on the effectiveness of opicapone in Parkinson’s disease patients with motor fluctuations: findings from the real-world OPTIPARK study

    W. Jost, H. Reichmann, A. Lees, D. Marinho, D. Magalhães, J. Rocha, P. Soares-da-Silva (Wolfach, Germany)

    Objective: This post-hoc analysis evaluated the influence of onset of motor fluctuation (OMF) on the response to opicapone (OPC) treatment in patients with Parkinson’s disease…
  • MDS Virtual Congress 2021

    Istradefylline/L-DOPA combination therapy for Parkinson’s disease and blood markers of glycolytic energy homeostasis

    NAO. Kanzato, KO. Nakachi, MA. Hayashi, F. Kinjyo, W. Mizuta, SA. Mochizuki (Haebaru-Cho, Okinawa, Japan)

    Objective: To clarify the potential to preserve glycolytic energy homeostasis (GEH) with the Istradefylline combined to L-DOPA (IST-LD), and to prevent LD-induced weight loss and…
  • MDS Virtual Congress 2021

    Evaluating a Novel Home-Based Care Pathway for People with Parkinson’s Disease

    E. King, J. Abraham, E. Edwards, T. Gorst, M. Holley, J. Inches, T. North, J. Rideout, S. Whipps, C. Carroll (Plymouth, United Kingdom)

    Objective: To evaluate the acceptability, feasibility, safety and effectiveness of a novel remotely delivered Parkinson’s care pathway. Background: Current care pathways for people with Parkinson’s…
  • MDS Virtual Congress 2021

    Neuroprotective Epigenetic and DNA-Repair Molecular Mechanisms of Acetyl-L-Carnitine and Astaxanthin Against 6-OHDA Induced Parkinsonism in Aged Rats

    S. Kumar, P. Kumar, A. Williams, M. Anifowose, K. Ponnusamy (Puducherry, India)

    Objective: Present study was designed to delineate the neuroprotective epigenetic and DNA-damage-repair molecular mechanisms of acetyl-L-carnitine (ALC) and astaxanthin (ASX) against  6-OHDA-induced neurotoxicity in aged…
  • MDS Virtual Congress 2021

    LY-487,379 enhances the anti-parkinsonian action of a low dose of L-DOPA in the MPTP-lesioned marmoset

    C. Kwan, I. Frouni, S. Nuara, S. Belliveau, A. Hamadjida, W. Kang, D. Bédard, J. Gourdon, P. Huot (Montreal, Canada)

    Objective: To investigate the effect of selective metabotropic glutamate type 2 (mGlu2) receptor positive allosteric modulation on the anti-parkinsonian action of a low dose of…
  • MDS Virtual Congress 2021

    Opicapone in Clinical Practice in Parkinson’s Disease UK Patients with Motor Fluctuations: Findings from the OPTIPARK Study

    A. Lees, H. Reichmann, D. Magalhães, J. Rocha, P. Soares-da-Silva (London, United Kingdom)

    Objective: To evaluate opicapone (OPC) when used in everyday clinical practice conditions to treat Parkinson’s disease (PD) patients with motor fluctuations. Background: OPC proved to…
  • MDS Virtual Congress 2021

    Effects of Once-Daily Opicapone 50 mg on the Pharmacokinetics of Levodopa Administered as Carbidopa/Levodopa Extended-Release Capsules: An Open-Label Phase 1 Study

    G. Loewen, A. Vijan, K. Olson, T. O’Reilly, G. Liang, O. Klepitskaya (San Diego, USA)

    Objective: To assess the effects of opicapone 50 mg on the pharmacokinetics (PK) of levodopa (LD) and its metabolite, 3-O-methyldopa (3-OMD), when administered with oral…
  • MDS Virtual Congress 2021

    Findings from a Community-based LOUD Crowd® Program for People with Parkinson Disease

    S. Parveen, A. Mandaville (Stillwater, USA)

    Objective: SPEAK OUT!® and LOUD Crowd® programs target the communicative functioning of people with Parkinson disease (PD). The current study includes findings from a year-long…
  • MDS Virtual Congress 2021

    OPTIMIPARK Questionnaire:a tool to optimize treatment in Parkinson´s disease.

    J. Máñez-Miró, F. Vivancos-Matellano, L. Vela-Desojo, R. Martinez-Fernandez, F. Alonso-Frech, N. Lopez-Aristegui, E. Balaguer-Martínez, J. Martinez-Castrillo, L. Lopez-Manzanares, P. Martínez-Martín (Madrid, Spain)

    Objective: To validate the OPTIMIPARK questionnaire as a tool to help the clinician in the adjustment of dopaminergic treatment in Parkinson´s disease(PD). Background: At early…
  • MDS Virtual Congress 2021

    Adherence to medication among Serbian Parkinson’s disease patients: a cross-sectional study

    A. Milovanović, B. Radojević, NT. Dragašević-Mišković, M. Svetel, I. Petrović, A. Tomić-Pešić, M. Savić, D. Stanisavljević, VS. Kostić (Belgrade, Serbia)

    Objective: This study aimed to explore patients’ adherence to antiparkinsonian medication, and to determine factors associated with low adherence among Serbian PD patients. Background: Adherence…
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