Unraveling the mechanisms of Tubulin Polymerization Promoting Protein TPPP/P25A degradation in oligodendrocytes
Objective: Our aim is to identify the proteolytic pathways responsible for the clearance of TPPP/P25A in oligodendrocytes, which may eventually represent potential therapeutic targets for…Cognitive assessment in a Greek cohort of Multiple System Atrophy patients.
Objective: The aim of the present study was to assess cognitive dysfunction in a Multiple System Atrophy (MSA) cohort and possible differences between disorder subtypes…Deep gray matter atrophy in MSA subtypes
Objective: To compare MRI parameters of atrophy in Multiple system atrophy (MSA) subtypes. Background: MSA is a rare adult-onset synucleinopathology that can be divided in…An Unusual Case of Multiple Systems Atrophy with Long Disease Duration, Severe Gliosis, and Scant Synuclein Pathology
Objective: To describe a pathologically unusual case of Multiple systems atrophy (MSA) with severe widespread gliosis and neuronal loss with scant alpha-synuclein (aSyn) pathology. Background:…Laryngeal Electromyography Findings in patients with Multiple System Atrophy
Objective: to systematically evaluate laryngeal electromyography findings, correlate them to laryngeal movement disorders assessed by a systematic task-protocol performed during FEES and clinical laryngeal symptoms.…The effect of sleep positions on morning orthostatic hypotension in Multiple System Atrophy patients: A pilot study
Objective: To determine the effect of sleep position on morning OH in MSA patients Background: Dysautonomia is considered as one of the most distress symptom…Sexual dysfunction in female patients with Multiple System Atrophy
Objective: To characterize sexual dysfunction in female patients with Multiple System Atrophy (MSA). Background: The diagnosis of probable MSA relies on the presence of parkinsonian…Longitudinal 18F-PBR06 (TSPO) and Volumetric MR Imaging as Pharmacodynamic Endpoints for MSA – Ongoing Investigator Sponsored Trial of Verdiperstat
Objective: In multiple system atrophy (MSA) patients to: 1) evaluate 18F-PBR06 positron emission tomography (PET) for longitudinal assessment of 18-kilodalton-translocator protein (TSPO) binding; 2) assess…Oligodendroglial-derived exosomes as mediators of α-synuclein pathology in MSA-like models
Objective: The current study focuses in elucidating the contribution of oligodendroglial-derived exosomes in the development and spread of α-Synuclein (αSyn) pathology in Multiple System Atrophy…Data-driven Subtype Classification of Patients with Early-stage Multiple System Atrophy
Objective: The objective of the present prospective study was to conduct latent class analysis (LCA) of a range of motor and nonmotor symptoms of MSA…
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