MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

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  • MDS Virtual Congress 2021

    Unraveling the mechanisms of Tubulin Polymerization Promoting Protein TPPP/P25A degradation in oligodendrocytes

    F. Arvanitaki, P. Mavroeidi, M. Vetsi, S. Becker, PH. Jensen, D. Vlachakis, L. Stefanis, M. Xilouri (Athens, Greece)

    Objective: Our aim is to identify the proteolytic pathways responsible for the clearance of TPPP/P25A in oligodendrocytes, which may eventually represent potential therapeutic targets for…
  • MDS Virtual Congress 2021

    Cognitive assessment in a Greek cohort of Multiple System Atrophy patients.

    A. Bougea, C. Koros, A-M. Simitsi, N. Papagiannakis, E. Efthymiopoulou, I. Pachi, C. Chrysovitsanou, R. Antonelou, V. Constantinides, E. Kapaki, L. Stefanis (Athens, Greece)

    Objective: The aim of the present study was to assess cognitive dysfunction in a Multiple System Atrophy (MSA) cohort and possible differences between disorder subtypes…
  • MDS Virtual Congress 2021

    Deep gray matter atrophy in MSA subtypes

    A. Campabadal, A. Abos, B. Segura, A. Perez-Soriano, D. Milena, E. Muñoz, Y. Compta, C. Junqué, M. Martí (Barcelona, Spain)

    Objective: To compare MRI parameters of atrophy in Multiple system atrophy (MSA) subtypes. Background: MSA is a rare adult-onset synucleinopathology that can be divided in…
  • MDS Virtual Congress 2021

    An Unusual Case of Multiple Systems Atrophy with Long Disease Duration, Severe Gliosis, and Scant Synuclein Pathology

    D. Coughlin, I. Dryden, B. Wright, S. Lessig, D. Galasko, A. Hiniker (San Diego, USA)

    Objective: To describe a pathologically unusual case of Multiple systems atrophy (MSA) with severe widespread gliosis and neuronal loss with scant alpha-synuclein (aSyn) pathology. Background:…
  • MDS Virtual Congress 2021

    Laryngeal Electromyography Findings in patients with Multiple System Atrophy

    F. Gandor, A. Vogel, A. Haghikia, G. Ebersbach, T. Warnecke, D. Gruber (Beelitz-Heilstätten, Germany)

    Objective: to systematically evaluate laryngeal electromyography findings, correlate them to laryngeal movement disorders assessed by a systematic task-protocol performed during FEES and clinical laryngeal symptoms.…
  • MDS Virtual Congress 2021

    The effect of sleep positions on morning orthostatic hypotension in Multiple System Atrophy patients: A pilot study

    T. Prasertpan, J. Sringean, R. Bhidayasiri (Bangkok, Thailand)

    Objective: To determine the effect of sleep position on morning OH in MSA patients Background: Dysautonomia is considered as one of the most distress symptom…
  • MDS Virtual Congress 2021

    Sexual dysfunction in female patients with Multiple System Atrophy

    C. Raccagni, E. Indelicato, V. Sidoroff, M. Daniaux, A. Bader, B. Toth, L. Jelisejevas, A. Fanciulli, F. Leys, S. Eschlboeck, C. Kaindlstorfer, S. Boesch, G. Wenning (Innsbruck, Austria)

    Objective: To characterize sexual dysfunction in female patients with Multiple System Atrophy (MSA). Background: The diagnosis of probable MSA relies on the presence of parkinsonian…
  • MDS Virtual Congress 2021

    Longitudinal 18F-PBR06 (TSPO) and Volumetric MR Imaging as Pharmacodynamic Endpoints for MSA – Ongoing Investigator Sponsored Trial of Verdiperstat

    T. Singhal, A. Pitaro, J. Kim, J. Woods, M. Mesidor, J. Ficke, A. Willett, S. Cicero, K. O'Connor, I. Qureshi, G. Young, V. Khurana (Boston, USA)

    Objective: In multiple system atrophy (MSA) patients to: 1) evaluate 18F-PBR06 positron emission tomography (PET) for longitudinal assessment of 18-kilodalton-translocator protein (TSPO) binding; 2) assess…
  • MDS Virtual Congress 2021

    Oligodendroglial-derived exosomes as mediators of α-synuclein pathology in MSA-like models

    M. Vetsi, G. Tsaka, P. Mavroeidi, F. Arvanitaki, M. Zweckstetter, S. Becker, PH. Jensen, L. Stefanis, M. Xilouri (Athens, Greece)

    Objective: The current study focuses in elucidating the contribution of oligodendroglial-derived exosomes in the development and spread of α-Synuclein (αSyn) pathology in Multiple System Atrophy…
  • MDS Virtual Congress 2021

    Data-driven Subtype Classification of Patients with Early-stage Multiple System Atrophy

    HJ. Yang, YJ. Jung, HJ. Kim (Ulsan, Republic of Korea)

    Objective: The objective of the present prospective study was to conduct latent class analysis (LCA) of a range of motor and nonmotor symptoms of MSA…
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