Acute administration of methylphenidate modulates functional connectivity during the processing of irrelevant stimuli in Parkinson’s disease patients
Objective: Examine the effects of a single dose of methylphenidate (MPD), on event-related functional connectivity (FC), in patients with Parkinson’s disease (PD). Background: Recent studies…Mild Motor Impairments in Rapid Eye Movement Behavior Disorder: Tremor and Bradykinesia
Objective: We investigated patients with RBD to identify mild motor impairments through the objective quantification of sensitive motor control assays. Background: It is established that…Exploratory Results From a Phase 1 Study of NIO752 in Progressive Supranuclear Palsy Supporting Further Clinical Studies
Objective: To report exploratory analyses of biomarker and clinical outcomes from a first-in-human study of NIO752 in progressive supranuclear palsy (PSP) and provide rationale for…Predicting Parkinson’s: Navigating Risk, Rights, and Regulation
Objective: This study explores the legal and ethical challenges surrounding predictive testing for Parkinson’s disease (PD), with a particular focus on its impact in employment,…Can a slogan poster featuring the patient’s primary physician help improve gait and prevent falls at home in patients with Parkinson’s disease?
Objective: To present cases with Parkinson’s disease (PD) suggesting that a slogan poster aimed at improving gait and preventing falls may be effective. Background: Patients…Proposal of Anatomo-Functional Tremor Patterns for Ultrasound-Guided Botulinum Toxin Infiltration
Objective: To propose a practical anatomo-functional framework for ultrasound-guided BoNT-A infiltration in upper limb tremor based on tremor biomechanics. Background: Botulinum toxin type A (BoNT-A)…Real-world database analysis of new-onset hypotension and medications for orthostatic hypotension prescribing patterns in patients with Parkinson’s Disease receiving MAO-B Inhibitors and levodopa in Japan
Objective: To evaluate the incidence of claims-defined new-onset hypotension and the prescribing patterns of medications for orthostatic hypotension in patients with Parkinson’s disease (PD) treated…Suicidal Ideation and the Hippocampal Histaminergic System in Huntington’s Disease: A PET Study
Objective: To determine whether presence and severity of suicidal ideation (SI) are associated with hippocampal volume and histamine H3 receptor (H3R) PET uptake in people with Huntington’s disease (PwHD). Background: Suicidal ideation occurs in approximately 8–27% of PwHD, yet its causes remain unclear(1–3). The…Integrated and Multidisciplinary Care for Older Adults with Parkinson’s Disease: A value-driven approach
Objective: To evaluate value driven outcomes of an integrated multidisciplinary Parkinson’s clinic for older adults in Singapore Background: Parkinson’s Disease (PD) is a complex neurodegenerative…Comparative efficacy and safety of Safinamide versus Opicapone in Japanese patients with Parkinson’s Disease and wearing-off: A matching-adjusted indirect comparison
Objective: To compare efficacy and safety outcomes with safinamide and opicapone as adjuncts to levodopa in Parkinson’s disease (PD) patients with wearing-off using an anchored…
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