Effects of dopaminergic medication on reinforcement learning in Parkinson’s disease depend on depressive symptoms
Objective: To investigate the effect of depression and dopaminergic medication on reinforcement learning (RL) in Parkinson’s disease. Background: Dopaminergic medication in PD is known to…Parkinson’s Disease, Cognitive Function and Medication Management: A Problem in Routine Care
Objective: Explore the relationship between objective and patient-reported assessment of cognition to patient-reported medication management capabilities. Background: Parkinson’s disease (PD) is a complex neurodegenerative disorder…Statistical methods for dealing with missing data in longitudinal studies with application to Parkinson’s disease cognition research
Objective: To assess the performance of standard techniques for handling missing data in longitudinal studies under a variety of missing data scenarios. We demonstrate our…The study of genetic factors in motor levodopa-induced complications development in Russian patients with Parkinson’s disease
Objective: The aim of our study is to search for genetic risk factors for the development of motor side effects of dopaminergic therapy, such as…Identification of a new Homozygous mutation P.R258Q In the gene SYNJ1 of an Algerian consanguine (inbred) Family suffering from early onset atypical Parkinsonism
Objective: The purpose of this observation is to demonstrate that autosomal recessive early parkinsonism is clinically and genetically heterogeneous Background: Early Onset Parkinson’s disease is…The Global Parkinson’s Genetics Program (GP2) – a year’s progress
Objective: The Global Parkinson’s Genetics Program (GP2, http://gp2.org/) aims to dramatically expand the current understanding of the genetic architecture of Parkinson’s disease (PD) and to…EIF4G1 gene variants in a family affected by Parkinson´s disease
Objective: Describe a novel mutation on a family affected by Parkinson´s disease. Background: 46 years old woman. She came to hospital complaining about tremor and…Digenic R1441G-LRRK2 and Parkin mutations in Parkinson’s Disease: first clinicopathological case report.
Objective: To report a clinicopathological case of digenic PD with R1441G- LRRK2 and PRKN mutations. Background: Digenic inheritance of R1441G-LRRK2 and PRKN mutation is extremely…Parkinson’s-disease risk variants are differentially associated with discrete phenotypic characteristics of Parkinson’s-disease at baseline.
Objective: Evaluate whether genetic risk variants for Parkinson’s disease discovered in case-control GWAS uniformly or differentially contribute to the clinical phenotype of PD. Background: Genetic…The application of Next Generation Sequencing in the Parkinson Disease.
Objective: This study aims to better investigating the pathogenetic of PD and improving the diagnostic approach in the molecular genetics, using the NGS. Background: Parkinson’s…
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