Ultrastructural Characterization of Monocytes in Parkinson’s Disease and GBA mutations
Objective: To identify morphological changes in circulating CD14+ monocytes in manifesting and non-manifesting carriers of mutations of the GBA gene and Parkinson’s disease (PD). Background: Mutations of…Serial DaT-SPECT imaging in asymptomatic carriers of LRRK2 G2019S mutation: 8-years follow-up
Objective: To characterize the 8-year progression of clinical and imaging biomarkers in a cohort of asymptomatic LRRK2 G2019S carriers and to assess its utility as predictors of…Parkinsonism in individuals with genetic neurodevelopmental disorders: A systematic review
Objective: It is increasingly recognized that individuals with genetic neurodevelopmental disorders (GNDs) such as 22q11.2 deletion syndrome can suffer from parkinsonism. We aim to provide…The Global Parkinson’s Genetics Program (GP2) Underrepresented Populations Working Group
Objective: GP2's Underrepresented Populations Working Group (WG) was created for individuals working within underrepresented/underserved populations to join forces to increase global representation and decipher the…Lack of diversity in Parkinson’s disease genetic research: current landscape and future directions
Objective: We conducted a systematic review to summarize past studies on Parkinson's disease (PD) genetics research among underrepresented populations (URP), defined as being non-European ancestry. We…Stratified genome-wide association study revealed novel interactions for the top hit Parkinson’s disease loci.
Objective: To identify genetic modifiers and interactors that may modulate known risk variants in the SNCA, TMEM175 and MAPT loci in Parkinson’s disease (PD). Background:…Remote assessment of prodromal Parkinson’s disease in a LRRK2 G2019S cohort
Objective: To compare remote application of the Movement Disorder Society (MDS) prodromal Parkinson’s disease (PD) criteria to expert clinical determination of possible parkinsonism in a…Genetic factors associated with dementia in Parkinson’s disease in the Parkinson’s Incidence Cohorts Collaboration (PICC)
Objective: To evaluate the effect of genetic variants in β-glucocerebrosidase (GBA), apolipoprotein E (APOE), microtubule-associated protein tau (MAPT), and α-synuclein (SNCA) loci on the risk…Gut dysbiosis in Parkinson’s disease with motor complications
Objective: We aimed to identify gut dysbiosis in Parkinson's disease patients with motor complications. Background: Recently, several evidences suggest that the gut microbiota is associated…Reduced serum PRDX3 levels are a biomarker for Asian LRRK2 carriers in Parkinson’s disease
Objective: We measured serum peroxiredoxin-3 (PRDX3) levels in Parkinson’s disease (PD) patients with and without LRRK2 risk variants, hypothesizing that PD LRRK2 carriers will show…
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