α-synuclein and deficits of membrane trafficking in Parkinson’s Disease
Objective: Aim of the study is to understand the physical and functional relationships between the PD-associated protein α-synuclein and some of the Soluble N-ethylmaleimide-sensitive-factor Attachment…Biomarker candidates – Peptides identified to be differentially abundant in cerebrospinal fluid of patients with Parkinson´s disease
Objective: The aim of this study was to identify cerebrospinal fluid peptides that are differential in the cerebrospinal fluid of patients with Parkinson´s disease. Those…Metabolic alterations in a Drosophila model of Parkinson’s disease
Objective: Identification of metabolic alterations that could be contributing to Parkinson’s disease (PD) physiopathology and become new biomarkers or therapeutic targets for the disease. Background:…RNA Editing in Parkinson’s Disease Shows Changes in Mitochondrial and Manganese-Binding Pathways in Multiple Brain Regions
Objective: To identify RNA editing alterations associated with Parkinson’s disease (PD) in the Dorsal Motor Nucleus of the Vagus (DMV), Substantia Nigra (SN), and Cingulate…Whole-transcriptome analysis of monocyte-derived macrophages from patients with Parkinson’s disease associated with mutations in the GBA gene
Objective: To understand specific molecular features of Parkinson’s disease associated with mutations in the GBA gene (GBA-PD), we analyzed the gene expression profile of peripheral-blood…Functional connectivity as an early marker of indication for deep brain stimulation treatment in Parkinson’s disease (PD)
Objective: To identify functional neuroimaging patterns anticipating the clinical indication for deep brain stimulation (DBS) in patients with PD. Background: DBS has become a well-established…Substantia nigra pars compacta integrity is associated with DRT-related motor symptom improvement in Parkinson’s disease
Objective: To study the correlation between substantia nigra white matter integrity and response of motor symptoms to dopamine replacement therapy (DRT) in Parkinson’s disease (PD).…Cortical microstructural alterations are more sensitive than morphology changes to cortical degeneration in Parkinson’s disease with mild cognitive impairment
Objective: To compare the sensitivity of detection cortical degenerative changes in patients with Parkinson’s disease (PD) and mild cognitive impairment (MCI) between the diffusion magnetic…Neurogenetic Traits Outline Vulnerability to Cortical Disruption in Parkinson’s Disease
Objective: In this study, we characterized the brain topological intersection between propagating connectivity networks in healthy controls (HC) and Parkinson’s disease (PD) participants and gene…Motor cerebro-cerebellar networks breakdown among different subtypes of Parkinson’s disease
Objective: The aim of this study was to investigate functional alterations within motor circuits of the cerebro-cerebellar system in tremor-dominant (TD) and postural instability and…
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