Lipid metabolism alterations in the lysosomal membrane promotes chaperone-mediated autophagy dysfunction and alpha-synuclein pathology in Parkinson’s disease associated to GBA
Objective: The objective of this study was to generate and characterize a new in vitro neuronal model of Parkinson's diseases associated to GBA (PD-GBA) that…Close relationship between CSF lipidomic alterations and cognitive decline in Parkinson’s disease.
Objective: To clarify what the lipidome of biological samples reflects in the pathology of Parkinson’s disease (PD). Background: The lipid pattern in the cerebrospinal fluid…Biofluid Biomarkers in Prodromal Parkinson’s Disease
Objective: To analyze biomarker signatures in biofluids in prodromal Parkinson’s disease (PD) to identify subjects at-risk to conversion and for progression. Background: Individuals at-risk for…CSF MicroRNA Analysis Reveals Angiogenesis And Autophagy Defects In Parkinson’s DiseasePatients
Objective: We investigated the effects of discoidin domain receptor (DDR)-1 inhibition on CSF miRNAs in Parkinson’s disease patients. Background: MicroRNAs (miRNAs) are post-transcriptional regulators of…Neurofilament light chain serum levels in E46K-SNCA mutation carriers
Objective: To demonstrate the usefulness of measuring the concentration of neurofilament light chain (NfL) in blood using Single Molecule Array matrix (SiMoA, Quanterix) as a…VPS35 D620N knockin mice recapitulate cardinal features of Parkinson’s disease
Objective: To establish the pathogenic effects of the PD-causing VPS35 D620N mutation in vivo and address possible underlying mechanisms. Background: D620N mutation in the vacuolar…PD phenotype with premotor RBD is associated with a dysbiotic profile of gut microbiota.
Objective: The aim of the study was to compare the fecal microbial composition of a group of PD patients with and without premotor RBD. Background:…Age-dependent multisystem parkinsonian features in a novel neuromelanin-producing transgenic mouse model
Objective: We aim to characterize the consequences of age-dependent intracellular neuromelanin accumulation in catecholaminergic neuronal populations to understand the relationship between this process and the…The Role Imposed by The High-Mobility Group Box 1 (HMGB1) Protein in MPTP-Induced Zebrafish Model of Parkinson’s Disease
Objective: This study aims to investigate the role of HMGB1 protein in mediating neuroinflammatory-induced parkinsonian movement disorder of the MPTP-induced zebrafish model of Parkinson's disease…Induction of Parkinsonian-like changes via targeted down-regulation of astrocytic glutamate transporter GLT-1 in the striatum
Objective: The aim was to explore the function and mechanism of astrocytic GLT-1 in PD-like changes. Background: Numerous researches suggest decreased expression of glutamate transporter-1…
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