Session Information
Date: Wednesday, June 22, 2016
Session Title: Rating scales
Session Time: 12:00pm-1:30pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: To revise the Non-Motor Sumptom Scale (NMSS) and develop a new up to date version, the MDS-NMS, a project commissioned by the International Parkinson and Movement Disorder Society (IPMDS). We report data from phases 1 (preliminary version) and 2 (pilot study).
Background: The NMSS was developed in 2006 and remains the only composite scale to assess the burden of NMS in Parkinson’s disease (PD) and needs updating.
Methods: Phase 1: A preliminary version of MDS-NMS (pvMDS-NMS) was developed including 15 domains with 63 items, each one scoring for frequency (0 to 4), severity (0 to 4), and a total score (frequency x severity; 0 to 16). Additionally, the scale includes an optional section for evaluating non-motor fluctuations (NMF) in 7 domains. Phase 2: A pilot study (UK and USA) was performed in 69 non demented PD patients and 19 healthy controls by 52 experienced evaluating neurologists using the neurologist-based pvMDS-NMS and questionnaires about the MDS-NMS for neurologists, patients, and controls. Statistical analysis addressed data quality, missing values, scores distribution, and preliminary reliability.
Results: The pvMDS-NMS scores were fully computable in 95.64%. Total pvMDS-NMS mean score (±SD) was 91.6±100.5 (range: 10–491). All domains, except Sleep and Wakefulness (7.2%) showed floor effect >15% (22.1–79.7%), but none had relevant ceiling effect (1.4–4.5%). Cronbach’s alpha index was satisfactory for 9/15 domains. Inter-item and Item-total correlations were globally satisfactory, and the item homogeneity index (standard value, >0.30) was satisfactory for most domains, except for Impulse control and related disorders, Other Neuropsychiatric symptoms, and Other Symptoms. The optional NMF section was completed by 71%, with similar findings in score distribution to the main pvMDs-NMS. In controls there were no missing values and the total pvMDS-NMS score (mean±SD) was 28.5±12.0 (range: 0-151). Over 80% of the neurologists opined that the scale was relevant, useful, and comprehensive, and < 5% reported length, wording, or scoring issues. The corresponding proportions for patients were >86% and <15%, respectively.
Conclusions: pvMDS-NMS showed satisfactory basic clinimetric attributes of the scale while some items and domains performed poorly. The definitive version of the MDS-NMS is now to be validated.
To cite this abstract in AMA style:
K. Ray Chaudhuri, D. Weintraub, A. Schrag, P. Martinez-Martin, On behalf of EUROPAR, The MDS Non-Motor PD Study Group. The International Parkinson and Movement Disorder Society – non-motor rating scale (MDS-NMS): Results from the cognitive pre-testing and phases 1 and 2 of an international validation [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/the-international-parkinson-and-movement-disorder-society-non-motor-rating-scale-mds-nms-results-from-the-cognitive-pre-testing-and-phases-1-and-2-of-an-international-validation/. Accessed December 9, 2024.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/the-international-parkinson-and-movement-disorder-society-non-motor-rating-scale-mds-nms-results-from-the-cognitive-pre-testing-and-phases-1-and-2-of-an-international-validation/