Session Information
Date: Tuesday, September 24, 2019
Session Title: Parkinsonisms and Parkinson-Plus
Session Time: 1:45pm-3:15pm
Location: Agora 3 West, Level 3
Objective: Compare two different cohorts of patients with the same pathology differentiated by age of onset.
Background: Multiple system atrophy (MSA) is a rare neurodegenerative disease and coordinated efforts are required to improve understanding, diagnosis, and treatment. Recently, Walsh RR et al. published some recommendations for Global MSA research including the creation of a unified dataset for MSA and implementation of a global international registry. In an attempt to reduce the knowledge gap in our region in 2014 we reported the preliminary data from PANMSA cohort. Two years later we implemented, a system with web domain database with a restricted access for site investigators to collect de-identified information to protect patient confidentiality that meets the required the Global MSA Registry (MDS MSA study Group) standards.
Method: Demographic and clinical data from MSA patients were collected until June 2018 and included in the new encrypted database.Inclusion criteria: >21 years old, fulfilling clinical diagnosis of MSA on the basis of the current consensus criteria for the disease. Exclusion criteria: Patients with any other causes of Parkinsonism.
Results: Hundred ten patients met criteria, We compare two cohorts: early onset MSA (40-49y/o) and late onset MSA (70- + y/o). Seven patients met criteria for e-MSA (6 Probable/Possible C; 1 Probable P). disautonomic failure were observed in all of them with Urinary Incontinence and orthostatism as most frecuent feature. Severe disability in HyY scale in 85%. The mean UMSARSII was 37.5. Unresponsive to levodopa was observed in 57%. Falls were reported in all of e-MSA. Four patient l-MSA (2 Probable/Possible C; 2 Probable/Possible), all of them with postural tremor. Autonomic disfunction was reported in 25%, only one with urinary failure, blue hands was present in 50%. Severe disability in HyY scale 25%. The mean UMSARSII was 15. Unresponsive to levodopa was observed in 75%.
Conclusion: The early cohort of MSA in the panamerican group looks to have more agressive clinical evolution. Urinary dysfunction, postural instability as well as falls were very disabling in the early cohort, with more impact on the Qol and clinical complications.
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To cite this abstract in AMA style:
M. Cesarini, E. Gatto, J. Etcheverry, G. da Prat, F. Peralta. To compare early / late onset MSA from the PAN American MSA (PANMSA) database [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/to-compare-early-late-onset-msa-from-the-pan-american-msa-panmsa-database/. Accessed December 10, 2024.« Back to 2019 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/to-compare-early-late-onset-msa-from-the-pan-american-msa-panmsa-database/