Prevalence of Parkinson’s disease and Drug-induced Parkinsonism from National Health Insurance Service Claims Data (NHISCD)
Objective: To evaluate the prevalence and characteristics of of drug induced parkinsonism Background: Drug induced parkinsonism (DIP) is a clinically important disease because it can…Imbalance between dopaminergic and cholinergic neurotransmission following rotenone administration suggestive of Parkinson’s-like symptoms in male rats
Objective: In the present study we analyzed rotenone-induced gait abnormalities, muscular weakness and locomotor deficits in rats. The study also evaluated the effects of rotenone…Using the power of a Network to accomplish a Countrywide Review of Acute Parkinson’s Disease management
Objective: To undertake a review of acute Parkinson’s management across different sites in Wales, a country that is part of the United Kingdom with a…Haploinsufficiency of KMT2B causes myoclonus-dystonia with impaired psychomotor ability
Objective: To investigate the genetic defect in patients with early-onset dystonia and myoclonus accompanying various neurological features. Background: Unlike other Mendelian disorders, dystonia genetics has…The Long-Term Safety of Deutetrabenazine for Chorea in Huntington Disease
Objective: To evaluate the safety and tolerability of deutetrabenazine in Huntington Disease (HD) over long term exposure. Background: In a randomized, double-blind, controlled trial (First-HD),…Effect of Pridopidine on Total Functional Capacity (TFC) in Huntington Disease (HD): Results of a Cohort Comparison of Open-HART and Historical Placebo Subjects
Objective: To measure functional decline by TFC change in HD patients treated with open-label pridopidine at 45 mg BID (Open-HART) for 36 months (mos), and…Myoclonus in adult onset Huntington’s disease
Objective: We present a case report of adult onset Huntington's disease (HD) with myoclonus as the main clinical feature. Background: Myoclonus is seldom reported as…Does cerebellar dysfunction contribute to tremor in Parkinson’s disease?
Objective: This study aims to investigate the potential role of cerebellar dysfunction in the pathogenesis of tremor in Parkinson’s disease (PD). Background: Rest tremor in…Alpha-synuclein enhances histone H3 lysine-9 dimethylation
Objective: To explore the nuclear function of alpha-synuclein (αS). Background: αS is a protein linked to Parkinson’s disease (PD) and related neurodegenerative disorders. It is…Mesencephalic astrocyte-derived neurotrophic factor reduces cell apoptosis via upregulating HSP70 in SHSY-5Y cells
Objective: The newest candidate growth factor for dopaminergic neurons is Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF). Signaling mechanisms by which MANF protects dopaminergic neurons from ER…
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