Tozadenant phase 3 study (TOZ-PD) in Parkinson’s disease patients with motor fluctuations: baseline characteristics
Objective: To describe the baseline characteristics of the TOZ-PD study population. Background: Tozadenant is an adenosine A2A antagonist under investigation as an adjunct to levodopa…Impaired sensorimotor and visual networks in drug naive Parkinson’s disease based on graph theoretical analysis
Objective: We aim to investigate topographic structure in drug naive patients with Parkinson’s disease (PD). Background: Resting state functional magnetic resonance imaging (rs-fMRI) provides valuable…99mTc-TRODAT-1 SPECT imaging in early and late onset Parkinson’s disease.
Objective: In this study we tried to determine the TRODAT SPECT findings in EOPD as compared to LOPD. Background: 99mTc-TRODAT-1, which binds to the dopamine…Writing training enhances neural connectivity in Parkinson’s patients with micrographia
Objective: To study network interactions of patients with Parkinson’s disease (PD) and healthy controls (CT) during handwriting with and without external visual cues and to…Action Observation Training Effects on Brain Structural and Functional Changes in Parkinson’s Disease Patients
Objective: To assess brain functional and structural changes following action observation training (AOT) associated with exercises of balance, gait, transfers and manual dexterity in Parkinson’s…Global Regulatory Agencies Support the Use of Dopamine Transporter Neuroimaging for Subject Selection in Clinical Trials Targeting Early Stage Parkinson’s Disease – on behalf of Critical Path for Parkinson’s (CPP) Consortium
Objective: A key goal of the Critical Path for Parkinson’s Consortium (CPP) is to qualify, with regulatory agencies, drug development tools for use in PD…Sleep disturbance may alter white matter and resting state functional connectivities in Parkinson’s disease
Objective: To clarify whether sleep disturbance would alter the patterns of structural and functional networks underlying cognitive dysfunction in patients with Parkinson’s disease (PD). Background:…Impacts of White Matter Hyperintensities on Limit of Stability in Drug-naïve, de novo Patients with Idiopathic Parkinson’s Disease
Objective: The aims of this study were to investigate the effects of incidental white matter hyperintensities(WMH) on self-initiated postural control in drug-naïve, newly diagnosed Parkinson disease…Increased hippocampal activation in Parkinson’s disease related amnestic mild cognitive impairment
Objective: To assess the functional significance of hippocampal network dysfunction in Parkinson’s disease related amnestic mild cognitive impairment (PD aMCI) using high-resolution functional neuroimaging. Background:…Hereditary spastic paraplegia type 31: a novel splice site donor mutation and intra-familial phenotypic variability
Objective: The aim of this study is to reveal molecular pathogenicity and genotype-phenotype correlations in Spastic Paraplegia type 31 (SPG31). Background: Mutations in REEP1 have…
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