Efficacy of incobotulinumtoxinA in patients with sialorrhea, as assessed using the modified Radboud Oral Motor Inventory for Parkinson’s disease (mROMP): Results of the SIAXI study
Objective: The pivotal double-blind, randomised Phase III SIAXI study (NCT02091739), assessed the efficacy and safety of incobotulinumtoxinA 75 or 100 U for sialorrhea. Co-primary endpoints…Clinical features of Parkinson’s disease with and without rapid eye movement sleep behavior disorder
Objective: Study the relationship between RBD and other symptoms of PD. Background: Rapid eye movement sleep behavior disorder (RBD) and Parkinson’s disease (PD) are two…Striatal dopamine transporter availability changes reflect gastrointestinal dysautonomia severity in early Parkinson’s disease
Objective: To test the hypothesis that constipation and gastrointestinal (GI) dysautonomia may be correlated with nigrostriatal dopaminergic (DA) dysfunction in PD. Background: Constipation is a…Sensory signs and neuropathic pain in advanced Parkinson’s disease under levodopa treatment
Objective: To evaluate whether patients affected by Parkinson’s disease (PD) under levodopa/carbidopa intestinal gel (LCIG) therapy have alterations in sensory symptoms and signs and/or painful…The Clinical Research of Parkinson’s Disease with Rapid Eye Movement Sleep Behavior Disorder
Objective: To compare the differences of clinical characteristics between PD patients with rapid eye movement sleep behavior disorder (RBD) (RBD+ group) and those without RBD…Is Heart Rate variability a differential biomarker in REM sleep behavior disorder, Parkinson’s disease, multiple system atrophy and progressive supranuclear palsy?
Objective: Heart rate deceleration capacity (DC) and heart rate variability index (HRVI) as potential biomarkers for autonomic dysregulation were studied in subjects (each group N=10)…Olfactory Hallucinations as a Non-motor sign of Parkinson’s disease – A cross-sectional study amongst patients in a tertiary movement center
Objective: Assess the prevalence of olfactory hallucinations (OlfH) in patients presenting to a tertiary movement disorders outpatient clinic. Background: Hallucinations can be considered a non-motor…Evaluation of Non-motor Symptoms of Parkinson’s Disease Patients in a Hong Kong Chinese population using the HK-NMSQuest
Objective: This study aimed to evaluate the non-motor symptom profiles of Hong Kong Chinese Parkinson’s Disease patients using the newly validated HK-NMSQuest, which is based…Objective intestinal dysfunction in REM sleep behaviour disorder
Objective: To study objectively measured intestinal function, defined by intestinal volume, transit times, and colonic motility patterns in patients with idiopathic REM sleep behaviour disorder…Influence of dopamine deficiency on interhemispheric crosstalk in Parkinson’s disease
Objective: To identify the significance of dopaminergic depletion in Parkinson’s disease (PD) on interhemispheric crosstalk using a complex bimanual tapping task. Background: Dopamine deficiency in…
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