Outcomes of the first-in-human study with a recombinant botulinum toxin E (rBoNT-E): safety and pharmacodynamic profile of rBoNT-E compared with abobotulinumtoxinA
Objective: To evaluate safety and pharmacodynamic (PD) profiles of the first recombinant botulinum toxins (BoNT) serotype E (rBoNT-E) versus abobotulinumtoxinA (aboBoNT-A) in healthy male volunteers.…Influence of baseline OFF-time in the efficacy response of Parkinson’s disease patients with motor fluctuations: post-hoc analysis from combined BIPARK-I and II
Objective: To evaluate the impact of baseline OFF-time on the efficacy of opicapone (OPC) in levodopa-treated Parkinson’s Disease (PD) patients with motor fluctuations. Background: OPC,…An open-label, 1-year extension clinical study in Japan of Opicapone treatment for Parkinson’s disease -Comfort-PD study part 2
Objective: To investigate the safety and efficacy of continuous treatment with 50 mg Opicapone (OPC) for 1 year after treatment with a placebo, 25 mg…INTREPID: A 2-Year Follow-Up of a Prospective, Double Blinded, Multi-Center Randomized Controlled Trial Evaluating Deep Brain Stimulation with a New Multiple Source, Constant-Current Rechargeable System for Treatment of Parkinson’s Disease
Objective: The objective of the INTREPID clinical trial assessed improvement in motor function and quality of life in patients with advanced, levodopa responsive Parkinson's disease…Brain MRI-based discrimination between multiple system atrophy type cerebellar from other late onset sporadic cerebellar ataxias: a prospective study with implications for diagnosis criteria
Objective: To evaluate, in patients with sporadic late-onset cerebellar ataxia (SLOCA), the discriminative value of each of the magnetic resonance imaging (MRI) features for the…Normative Reference for Timed Up and Go Test (TUG) in Young Indian Adults- Preliminary Results
Objective: This study investigated the clinical usefulness of the time up and go test in young population and provide a reference range for healthy adults.…Non-CpG methylation in the FXN gene in patients with Friedreich’s ataxia
Objective: To compare methylation profiles of non-CpG sites in the FXNgene in patients with Friedreich’s ataxia (FA), their heterozygous relatives and a healthy control group. Background: FA is…Alcohol- Induced Cerebellar Ataxia
Objective: To verify vestibulocochlear disorders observed in a case of alcohol-induced cerebellar ataxia. Background: Alcohol-induced cerebellar degeneration is the commonest type of acquired toxic ataxia,…Sydenham’s chorea: Clinical features and treatment outcome
Objective: To study the clinical features, investigations and treatment outcome in Sydenham’s chorea patients. Background: Sydenham’s chorea is one of the major clinical manifestations of…The short-term effect of combined facial exercise with botulinum toxin A injection in clinical practice in Thai patients with hemifacial spasm: A randomized controlled pilot crossover study
Objective: To compare the efficacy of combined facial exercise with BTX-A injection with BTX-A injection alone measured by the total HFS-30 (tHFS-30) score. Background: Hemifacial…
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