4-Chlorokynurenine inhibits L-Dopa-induced dyskinesias in non-human parkinsonian primates
Objective: This study investigated the antidyskinetic activity of 4-chlorokynurenine (AV-101) in parkinsonian monkeys with L-Dopa-induced dyskinesias. Background: The common treatment for Parkinson’s disease (PD) is L-Dopa…Frontal Cavernous angioma manifested as acquired dystonic tremor: Two case reports
Objective: To highlight unilateral slow dystonic tremor as an uncommon presentation of frontal cavernoma. Background: Acquired dystonia, results from injury to the brain, poisoning or…Long-term effect of non-invasive Vagus Nerve Stimulation in Parkinson’s disease patients
Objective: In this first ever, randomized, double-blind control trial we explored the role of noninvasive VNS (nVNS) in the treatment of gait and motor symptoms…Measurement of speech as a biomarker of neurodegenerative disease using acoustic profiles and machine learning
Objective: To examine the utility of speech biometrics for describing and delineating neurodegenerative diseases using acoustic measures and machine learning procedures. Background: Progressive neurological disorders…Palliative care and Parkinson’s disease: current practice, knowledge and barriers to referral; Insights from palliative care units in Brittany, France
Objective: To assess the current practice regarding patients with Parkinson’s disease (PD) in palliative care units and to identify barriers to patients’ referral and optimal…A brain signature of prodromal Lewy body dementia
Objective: To investigate the presence of a brain signature able to predict the development of dementia in patients with idiopathic REM sleep behavior disorder (iRBD).…Cholinergic basal forebrain atrophy and cognitive decline in advanced Parkinson’s disease
Objective: To examine the relationship between cognitive decline and atrophy across cholinergic basal forebrain (BF) subregions in advanced Parkinson’s disease (PD). Background: Recent studies show…The relationship between REM sleep behavior disorder and cognitive impairment in drug-naïve Parkinson’s disease
Objective: We aim to compare the cognitive performances of drug-naïve PD patients who had RBD (PD-RBD) to PD patients without RBD (PD-NRBD) and healthy controls.…Associations between subjective and objective cognitive decline in Parkinson’s disease
Objective: To evaluate associations between objective and subjective cognitive function over time in Parkinson’s disease (PD) using data from a clinical trial that enrolled patients…Anticholinergic Use in Parkinson’s Disease: Practice Patterns in Patients with Cognitive Impairment
Objective: To explore utilization of anticholinergic medications using the Parkinson Foundation Quality Improvement Initiative (PF-QII) registry. Background: Recent publications have highlighted the association between anticholinergic…
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