Hand Fine Motor Performance Capacity is Associated with the Cognition in People with Moderate to Advanced Parkinson’s disease
Objective: This study aims to investigate the association between the hand fine motor performance with the cognitive dysfunction in people with moderate and severe PD.…Parkinson’s disease polygenic risk score and brain structure in neurologically healthy individuals
Objective: To investigate the relationship between Parkinson’s disease-polygenic risk score (PD-PRS) and brain morphology in a large sample of healthy individuals. Background: PD is caused…Beta-Glucocerebrosidase Activity in GBA-linked Parkinson’s Disease: The Type of Mutation Matters
Objective: To test the relationship between clinically relevant types of GBA mutations (none, risk variants, mild mutations, severe mutations) and beta-glucocerebrosidase activity in patients with…Parkinson’s disease polygenic risk prediction and haplotype analysis in a South American cohort
Objective: We aim to evaluate the performance of a Parkinson’s disease (PD) polygenic risk score (PRS), estimated using genome-wide association (GWAS) data from a European…GPNMB protein levels in CNS are modulated by PD risk variant rs199347
Objective: This study evaluates protein quantitative trait loci (pQTL) effect of single nucleotide polymorphism (SNP) rs199347 in modulating glycoprotein non-metastatic melanoma protein B (GPNMB) expression…SNPs in SNCA, MCCC1, DLG2, GBF1, and MBNL2 are associated with Parkinson’s disease in southern Chinese populations
Objective: This study aimed to replicate the relationship between 12 novel SNPs of 12 genes and PD risk in southern Chinese populations. Background: Numerous single-nucleotide polymorphisms (SNPs), which have…Alpha-synuclein DNA methylation in CD45+ blood cells in Parkinson’s disease
Objective: We examined the methylation status of the DNA SNCA-intron1 at CD45+ blood cells in patients with sporadic Parkinson's disease (PD). Background: PD is a…Increased expression of conexin 36 in rodent model of Parkinson disease
Objective: To evaluate changes in non-synaptic mechanisms associated with the procedures to reproduce the neurophysiological conditions typical of Parkinson's disease (PD). Background: Many mechanisms that…Structural and microstructural pathology in early de novo Parkinson’s disease patients with depression: An MRI study
Objective: To investigate structural and microstructural pathology in early de novo Parkinson’s Disease (PD) patients with depression, using Magnetic Resonance Imaging (MRI). Background: Depression is…Motor cerebellar connectivity and future development of freezing of gait in de novo Parkinson’s disease
Objective: To investigate the role of motor cerebellar connectivity in future development of freezing of gait (FoG) Background: Freezing of gait (FoG) in Parkinson’s disease…
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