A Systematic Review of the Type, Timing, Frequency and Durability of Effect in Parkinson’s Disease Physical Therapy
Objective: To evaluate all current evidence on the types, timing, frequency, duration, and outcomes of physical therapy (PT) regimens applied in Parkinson’s disease (PD). Background:…Prevalence of cogwheel phenomenon in Parkinson disease
Objective: To examine the prevalence of cogwheel rigidity (CWR) in a cohort of Parkinson disease (PD) patients Background: First noted in a 1901 publication, CWR…Glucocerebrosidase (GCase) activator, Ambroxol, reduces alpha-synuclein serine-129 phosphorylation and oligomers in mutant LRRK2 R1441G mouse brains
Objective: To explore whether inducing brain GCase activity by Ambroxol™ (ABX; a brain-penetrant GCase activator) can reduce a-synuclein (αSyn) serine-129 phosphorylation and oligomer accumulation in…Functional circuit abnormalities in Levodopa-induced dyskinesia in Parkinson’s disease: A systematic review
Objective: Levodopa-induced dyskinesia (LID) in Parkinson’s disease (PD) are involuntary movements caused by long-term treatment with dopaminergic replacement therapy (levodopa). During the cause of PD,…Frequency coding mechanism of tremor in the cerebellar circuitry
Objective: Tremor is an involuntary rhythmic movement. However, the frequency-coding mechanism of tremor remains unknown. This study aims to identify such mechanism in the central…VALIdation of models for assessing eligibility for referral for Device-Aided Treatment in Parkinson’s disease (VALIDATE)
Objective: To externally validate the Dutch Device-Aided Therapy Screening tool (D-DATS) and to compare it with the 5-2-1 criteria. Background: Timely identification of patients with…Mosaic divergent repeat interruptions in X-linked dystonia-parkinsonism: stability over generations and time
Objective: This study aims to investigate the stability of Mosaic Divergent Repeat Interruptions affecting motif Length and Sequence (mDRILS) frequencies and repeat length across generations…A novel, population-specific PINK1 p.F385S loss of function mutation in an Indian family with Parkinson’s disease
Objective: To understand the molecular function of a novel missense PINK1 variant identified in an Indian family with Parkinson’s disease (PD). Background: The molecular understanding…Sympathetic tone abnormalities in subjects at risk for Parkinson’s Disease without evidence of nigrostriatal neurodegeneration: a multimodal biomarker study
Objective: To study autonomic dysfunction in subjects with idiopathic REM sleep behavior disorder (iRBD) and at least one pre-motor symptom of Parkinson's disease (PD). Background:…Testing gene-environment interaction in Parkinson’s disease (PD) using whole-genome sequencing of pesticide-exposed cohorts.
Objective: To identify interactions of specific pesticides with genetic loci to find causal variants for PD using gene burden analysis (BA). Background: Pesticide exposure is…
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