A Study to Evaluate the Efficacy and Safety of Intravenous Prasinezumab in Participants with Early Parkinson’s Disease (PADOVA): Rationale, Design, and Baseline Data
Objective: To evaluate the effect on slowing motor progression and the safety of prasinezumab, a humanized monoclonal antibody targeting aggregated alpha-synuclein, in individuals with early…Distinct pattern of synaptic loss in Parkinson’s disease depression and initial findings from the Yale Ketamine PD (KET-PD) trial
Objective: To investigate synaptic loss in Parkinson's Disease depression (PDd) using PET and [11C]UCB-J (a marker for synaptic density) and present the initial blinded findings…Exploring the Neuroprotective Potential of Mushroom Extracts in Parkinson’s Disease In-Vitro Models
Objective: This study investigates the potential neuroprotective effects of several mushroom extracts in PD in-vitro models. Background: Parkinson's disease, a progressive condition, involves dysfunction or…Spray with Nasal Mucoadhesive Microspheres for Treating Parkinsonism.
Objective: Although levodopa is the preferred medication for treating Parkinson's disease, it has a very poor brain absorption and limited oral bioavailability. The goal of…Aerobic Exercise in Non-Exercisers with Advanced Parkinson’s Disease (PD) and Deep Brain Stimulation (DBS): A Pilot Study
Objective: To assess the feasibility of an aerobic exercise regimen in those with advanced PD and DBS. Background: Aerobic exercise is known to have beneficial…AAV-mediated gene therapy for GBA-PD
Objective: Development of a gene therapy-based drug for treatment of GBA-PD, a genetic subtype of Parkinson’s disease Background: Mutations in GBA1, the gene encoding glucocerebrosidase…Prediction of The Monopolar Review in Deep Brain Stimulation for Parkinson’s Disease using Imaging
Objective: To build an AI model that can predict the monopolar review in deep brain stimulation (DBS) for Parkinson’s disease (PD) based on imaging. Background:…Effectiveness of Subthalamic nucleus (STN) Deep Brain Stimulation Surgery (DBS) in patients with Parkinson’s Disease: A Patient and Caregiver reported outcome
Objective: We aim to assess the subjective impression on effectiveness and safety of Subthalamic nucleus Deep Brain Stimulation Surgery (STN-DBS) in patients with Parkinson’s Disease…The Protective Role of Lysosomal Damage Response in Preventing α-Synuclein Propagation
Objective: The aim of this study was to investigate the mechanism by which the lysosomal damage response (LDR) defends against the escape of α-synuclein (αSyn)…Parkin regulates ER-mitochondria association through interaction with IP3R-Grp75-VDAC1
Objective: The objective of this study is to explore how Parkin modulates the interplay between mitochondria and the endoplasmic reticulum (ER), along with elucidating its…
- « Previous Page
- 1
- …
- 21
- 22
- 23
- 24
- 25
- …
- 181
- Next Page »