Polyamine pathways: a promising frontier for biomarkers and therapeutic targets in Parkinson’s disease (PD)
Objective: To systematically modulate polyamine (PA) metabolic pathways and investigate PA biomarker findings in PD using Drosophila melanogaster over-expressing human wild-type α-synuclein gene (hSNCA). Our…Machine Learning Model Comparison for Freezing of Gait Prediction in Advanced Parkinson’s Disease Patients
Objective: This study compares the performance of machine learning classification models in predicting freezing of gait (FoG) from instrumented stand-and-walk trials in advanced Parkinson’s disease…Differentiating Progressive Supranuclear Palsy from Corticobasal Syndrome Using Cortical Diffusion MRI
Objective: To compare cortical microstructural measures in Progressive Supranuclear Palsy (PSP) and Corticobasal Syndrome (CBS) using cortical diffusion magnetic resonance imaging (MRI). Background: Differential diagnosis…Sex-Related Differences of Resting-State Brain Activity in Parkinson’s Disease
Objective: To investigate sex-related differences of resting-state functional magnetic resonance imaging (rs-fMRI) metrics in early-stage, untreated Parkinson’s disease (PD) patients. Background: Sex plays an important role in the heterogeneity of PD, but its effects…Cortical morphometry and subcortical volumetry in motor subtypes of Parkinson’s disease
Objective: This study aims to evaluate the presence of differences in cortical morphometry and subcortical volumetry in tremor dominant Parkinson’s disease (TDPD) and postural instability…the Degeneration of Locus Coeruleus and its Enhanced Causal Relationship to Neural Circuit in Parkinson’s Tremor
Objective: We aim to decode the neuroimaging features of LC in Parkinson's tremor. Background: Tremor is the primary symptom of Parkinson's disease (PD) and exhibits…Cholinergic brain vulnerabilities associate with diabetic comorbidity in Parkinson disease
Objective: We aim to explore differences in brain cholinergic nerve terminal integrity between Parkinson's disease (PD) patients with and without comorbid diabetes, utilizing a highly…Enlarged Perivascular Spaces in the Temporal Lobe as a Predictor for Incident Dementia in Parkinson’s Disease
Objective: To evaluate the whether regional burden of enlarged perivascular space (EPVS) hold prognostic value in predicting the dementia conversion in Parkinson's disease (PD). Background:…Cardiac Mitochondrial Complex I Integrity Predicts Axial Symptom Severity in Parkinson’s Disease
Objective: In the present work, we investigated whether cardiac mitochondrial dysfunction might also be associated with the severity of PIGD symptoms in PD patients. Background:…Deep brain stimulation for severe dystonia associated with Wilson’s disease: A prospective multicentre meta-analysis of Nof1 trials
Objective: To assess the efficacy of the deep brain stimulation (DBS) on dystonia in Wilson’s disease (WD). Background: The persistence of disabling dystonia despite medical…
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