A Comparison of Coordinated Reset and Low-Frequency Vibrotactile Stimulation for the Treatment of Parkinson’s Symptoms
Objective: This research examines a novel non-invasive vibrotactile device which stimulates fingertips in a pattern aiming to disrupt pathological physiological beta-band oscillations believed to be…Phase I randomized, double-blind study to evaluate feasibility, safety, and clinical responses of implanting autologous peripheral nerve tissue into the nucleus basalis of Meynert or substantia nigra for non-motor or motor symptoms in patients with Parkinson’s disease undergoing DBS surgery (STAR) Trial
Objective: To evaluate the feasibility, safety, and clinical responses of bilateral delivery, at the time of deep brain stimulation (DBS) surgery, of autologous peripheral nerve…LRRK2 Pathway Inhibition By NEU-411, a Potent, Selective, CNS-Penetrant LRRK2 Inhibitor In Healthy Participants
Objective: The aim of this work was to evaluate LRRK2 pathway modulation by the potent, selective, CNS-penetrant LRRK2 inhibitor NEU-411 in healthy adults and elderly…Establishing and Leveraging a Community Advisory Board to Guide Study Design, Speed Recruitment and Encourage Retention
Objective: To describe the formation and impact of the Parkinson’s Progression Markers Initiative (PPMI) Community Advisory Board (CAB). Background: Community advisory boards are critical partners…Solengepras: An Investigational Therapy with Potential Benefits on Functional and Non-Motor Measures in Parkinson’s Disease (PD)
Objective: Solengepras is a GPR6-inhibitor that is being studied as an investigational treatment for Parkinson’s Disease (PD). Background: GPR6 is a novel G-protein-coupled receptor found…Ferritin-related Brain Iron Deposition in Parkinson’s Disease Involves α-Synuclein Pathology
Objective: To investigate plasma neuron-derived ferritin-containing extracellular vesicles (NDFEVs) differences between Parkinson’s disease (PD) patients and controls, assess their association with brain iron deposition, and explore the…The A53T mutation in alpha-synuclein impairs astrocytic metabolism and inflammatory response
Objective: This study aims to explore the impact of the A53T alpha-synuclein (α-syn) mutation on astrocytic homeostasis and metabolism in the presence of inflammatory stimuli.…Disease Modifying Potential of a Novel ROCK Inhibitor in Rodent Models of Synucleinopathy
Objective: Evaluate the impact of a novel Rho-associated kinase (ROCK) inhibitor on alpha-synuclein (a-syn) pathology, neuroinflammation, and dopamine neurodegeneration in the AAV-a-syn overexpression and a-syn…Gastrointestinal Dysfunction and Levodopa Therapeutic Response in Parkinson’s Disease: A Brazilian Cross-sectional Study
Objective: To investigate the relation between constipation and the onset time of levodopa therapeutic effect in Parkinson's disease (PD). Background: Levodopa therapeutic response depends on…Clinical Picture of Acute Akinetic Collapse Leading to Multi-Day Immobility in Parkinson’s Disease
Objective: To investigate the clinical characteristics of Parkinson's disease (PD) patients who experienced acute akinesia and immobilization requiring emergency medical care. Background: PD patients sometimes…
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