A Proof-of-Concept Study of TR-012001, a Nasal Levodopa, in Patients With Parkinson’s Disease With OFF Episodes, Without Dopa Decarboxylase Inhibitor
Objective: To evaluate the safety, tolerability, levodopa pharmacokinetics, and exploratory efficacy of TR-012001 in Parkinson’s disease (PD). Background: TR-012001 is a novel investigational prefilled nasal…Efficacy and safety of Rotigotine Extended-Release Microspheres in Early Parkinson’s Disease
Objective: To assess the efficacy and safety of Rotigotine extended-release microspheres (LY03003) in patients with early Parkinson's disease Background: Treatment that provides a continuous flow of…Adaptive Deep Brain Stimulation for Parkinson’s Disease in Routine Clinical Care: First Experiences
Objective: To describe the treatment process and outcomes of the first patients with Parkinson’s disease (PD) treated with adaptive DBS (aDBS) within routine clinical care…Long-term effects of a periodic intensive rehabilitation program in People with Parkinson’s Disease
Objective: This study aimed to examine the long-term effects of a periodic intensive rehabilitation program incorporating tele-tools on the progression of motor symptoms in people…Assessment of the impact of the diabetic features hyperglycemia and insulin resistance on fibril induced synucleinopathy
Objective: Investigate the effects of diabetic features on the induction and severity of synucleinopathies such as Parkinson’s disease (PD). Background: Type 2 diabetes (T2D) is…Association Between Heterozygous Loss-of-Function Variants in the MCOLN1 Gene and α-Synucleinopathies
Objective: To evaluate the association between heterozygous loss-of-function variants in the MCOLN1 gene and α-synucleinopathies. Background: Lysosomes play a crucial role in cellular waste disposal,…Comparative Analysis of miR-29a Expression in Optimized Medical Therapy and Intestinal Infusion Therapies in Advanced Parkinson’s Disease
Objective: To compare the relative expression of miR-29a in patients with advanced Parkinson's disease (PD) receiving optimized medical therapy (OMT) versus intestinal infusion therapies—levodopa/carbidopa intestinal…The Effectiveness of Rivastigmine in Parkinson’s Disease: Impact on Motor Symptoms, Gait, Cognitive Function, and Falls – A Systematic Review and Meta-Analysis of Double-Blind, Placebo-Controlled RCTs
Objective: To evaluate the efficacy of rivastigmine in patients with Parkinson’s disease (PD) by assessing its impact on motor symptoms, cognitive function, gait, falls, and…Positive Relationship Between Improvement in Sleep and Quality of Life During Foslevodopa/Foscarbidopa Continuous Subcutaneous Infusion
Objective: To investigate the relationship between improvements in sleep disturbances and quality of life (QoL) in adults with advanced Parkinson’s disease (aPD) treated with a…Continuous Subcutaneous Dopaminergic Stimulation: Exploring the impact of Foslevodopa/Foscarbidopa on Gait in Parkinson’s disease.
Objective: The primary objective of this study is to investigate the effect of continuous subcutaneous infusion (CSCI) of foslevodopa/foscarbidopa (FL/FC) on gait in those with…
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