People With Parkinson’s Disease and Care Partners Experience Costly Work Productivity Loss
Objective: To evaluate work productivity loss (WPL) and associated costs among people with newly diagnosed Parkinson’s Disease (nPD), advanced PD (aPD), and care partners (CP).…Clinical Characteristics of Parkinsons Disease and their Role in Differential Diagnosis
Objective: To study and systematize the clinical characteristics of Parkinson's disease (PD) and their role in differential diagnosis with other parkinsonian syndromes. Background: Parkinson’s disease…GCase and Ganglioside GM1 Interaction in Parkinson’s Disease
Objective: The project aims to further understand the role of the ganglioside GM1 in the relationship between GBA1 mutations and higher α-synuclein levels. Background: Among…Complement C4 Exacerbates Inflammation and Neuronal Damage in Vivo
Objective: To investigate the specific effects of the core complement component C4 on α-synuclein aggregation and neuroinflammation during the pathogenesis of PD. Background: Synucleinopathies are…Longitudinal Brain Morphometric Trajectories Across Parkinson Disease Clinical Subtypes
Objective: To investigate longitudinal brain morphometric trajectories across Parkinson disease (PD) clinical subtypes Background: We developed a PD multi-domain classification based on motor and non-motor…Mathematical and Computational Modeling Prototype to Understand the Evolution of Parkinson’s disease using Four Differential Equations
Objective: Apply four differential equations to generate projections considering the effect of dopamine on Parkinson’s disease progression, leading to the development of an initial prototype…Prevalence and Clinical Characteristics of iNPH-Related Imaging Findings (DESH) in Parkinson’s Disease
Objective: To investigate the prevalence of idiopathic normal pressure hydrocephalus (iNPH)-related imaging findings (DESH) and their clinical characteristics in Parkinson’s disease (PD) patients. Background: PD…Semi-quantitative Evaluation of Midbrain Accumulation in 123I-FP-CIT SPECT in Parkinson’s disease and Parkinsonian Syndromes
Objective: To establish a method for evaluating midbrain accumulation of 123I-FP-CIT SPECT and assess its ability to differentiate between Parkinson’s disease (PD) and Parkinsonian syndromes…Prospective Tractography-Guided STN DBS Targeting with Optimized vmPFC Connectivity for Apathy in PD a Case Report
Objective: Prospective tractography-guided DBS targeting of the left STN-vmPFC and primary motor pathway to improve apathy alongside motor symptoms in PD. Background: While STN DBS…Uncovering the heterogeneity of spatiotemporal trajectories of neurodegeneration in Parkinson’s disease: an early-phase 18F-FP-CIT PET study
Objective: To define the subtypes of Parkinson’s disease (PD) based on the spatiotemporal progression patterns of cerebral hypoperfusion. Background: Early-phase 18F-FP-CIT PET images, which are…
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