Longitudinal Analysis of BRAIN test in isolated REM sleep behaviour disorder with and without hyposmia.
Objective: To assess motor dysfunction in individuals with polysomnography (PSG)-confirmed isolated REM Sleep Behaviour Disorder (iRBD), self-reported RBD (sRBD), and sRBD with smell loss (hyposmia).…P2P Therapeutics Platform Trial in Stage 2B Neuronal Alpha-Synuclein Disease: Study Design and Statistical Considerations
Objective: To describe the study design and timeline of a platform interventional study in Neuronal α-Synuclein Disease (NSD). Background: The recent description of the biological…The Benefits of Whole-Body Electro Muscle Stimulation (WB-EMS) in a patient with Parkinson’s Disease
Objective: To determine the motor and non-motor benefits of WB-EMS in a patient with Parkinson’s disease Background: Parkinson’s disease causes both motor and non-motor symptoms.…Comparative efficacy of opicapone and entacapone in the management of motor fluctuations in Parkinson’s disease
Objective: To compare the clinical efficacy of two catechol-O-methyltransferase (COMT) inhibitors, opicapone (OPC) and entacapone (ENT). Background: OPC and ENT are used as adjunctive therapy…GT-02287 in Parkinson’s Disease: Interim Data from a Phase 1b Study
Objective: To evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of the brain-penetrant glucocerebrosidase (GCase) modulator GT-02287 in people with Parkinson’s disease with and without a…Improvement of Freezing of Gait with Personalized Rhythmic Auditory Stimulation in Parkinson’s Disease
Objective: To determine if different types of personalized music rhythmic auditory stimulation (RAS) training can improve gait control in Parkinson's Disease (PD) patients with freezing…Efficacy and Safety of IPX203 and Levodopa-Carbidopa Intestinal Gel (LCIG) Compared to Immediate-Release Carbidopa-Levodopa in Parkinson’s Disease: A Systematic Review and Meta-Analysis
Objective: To conduct the efficacy and safety of IPX203, an extended-release carbidopa-levodopa formulation, and LCIG, a continuous levodopa infusion, compared to Immediate-Release Carbidopa-Levodopa (IR CD-LD)…Effect of Reaction Oriented Training on Postural Stability and Reaction Time in Parkinsons’s Disease
Objective: This study aimed to examine the effect of reaction-oriented training (ROT), a novel rehabilitation approach developed for people with Parkinson's disease (pwPD), on postural…Correlations of catecholamine metabolites and alpha-synuclein by nigral stimulation in Parkinson’s disease model rat
Objective: We aimed to clarify the effects of substantia nigra (SN) stimulation on catecholamine levels and α-synuclein in PD model rats. Background: Catecholaminergic neurons are…A retrospective study on thyroid dysfunction mimicking Parkinsonian symptoms
Objective: This retrospective study analyzes outcomes of nine patients (three females, six males) admitted to the endocrinology department from 2020 to 2024. Initially diagnosed with…
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