One-Year Outcomes of Radiofrequency Thalamotomy Versus MR-Guided Focused Ultrasound: A Prospective Single-Centre Comparative Study
Objective: To prospectively compare 1 year clinical efficacy and safety following RF and MRgFUS thalamotomy in essential tremor. Background: Ventral intermediate nucleus (VIM) thalamotomy is…PPP2R2B Splice Variant Dysregulation Promotes Mitochondrial Association and Neuronal Apoptosis in iPSC-Derived Neurons from Spinocerebellar Ataxia Type 12 Patient
Objective: This study aimed to investigate the impact of PPP2R2B mutation in Spinocerebellar Ataxia Type 12 (SCA12) by analysing PPP2R2B splice variant expression, subcellular localization,…Resting-state functional network alterations in early Parkinson’s disease anxiety: a 7T MRI study
Objective: To investigate alterations in functional connectivity (FC) within and between key resting-state networks in early Parkinson’s disease patients with anxiety, using 7-Tesla (7T) MRI.…Microsaccade Alterations and Clinical Correlates in Parkinson’s Disease
Objective: To delineate microsaccade dynamics in people with Parkinson’s disease (PD) compared with healthy controls (HC) and to examine their associations with disease-related dysfunction. Background:…Correlating Start Hesitation and Subthalamic Nucleus Activity in Parkinson’s Disease Using Intraoperative Microelectrode Recordings and a Virtual Reality Task
Objective: To investigate the modulations in subthalamic nucleus (STN) signals that are associated with prolonged gait initiation duration in a virtual reality gait task in…PET Imaging of Presynaptic Terminals with [18F]SynVesT-1 in Premanifest Huntington’s Disease
Objective: To assess synapse loss in vivo in late premanifest Huntington’s disease (HD) subjects using [18F]SynVesT-1 positron emission tomography (PET). Background: Synaptic damage is believed…Tremorography as an objective marker of the response after MRgFUS VIM in essential tremor and Parkinson’s disease
Objective: To assess tremorography as an objective tool for evaluating response to MR-guided focused ultrasound (MRgFUS) ventral intermediate nucleus (VIM) thalamotomy in essential tremor (ET) and Parkinson’s…Systemic Inflammation and Cerebral Small Vessel Disease in Progressive Supranuclear Palsy
Objective: To assess the cerebral small vessel disease (CSVD) burden in progressive supranuclear palsy (PSP) and examine the relationships among peripheral inflammatory markers, CSVD imaging…Adaptive Deep Brain Stimulation in Parkinson Disease: Preliminary Single-Center Results
Objective: To describe initial outcomes of alpha-beta (8-30Hz)-guided subthalamic nucleus (STN) adaptive deep brain stimulation (aDBS) in Parkinson disease (PD) in a single-center cohort. Background:…Resting-state pupil fluctuations reflect monoaminergic brainstem dysfunction associated with non-motor symptoms in early Parkinson’s disease
Objective: To determine whether resting-state pupil fluctuations reflect structural and functional impairment of monoaminergic brainstem nuclei and are associated with non-motor symptom burden in early…
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