Clinico-radiological Phenotype of a Unique Family with Mutations in PRKN Over Three Decades
Objective: To report the clinico-radiological phenotype and progression of a female proband and her parents with mutations in the PRKN gene. Background: Bi-allelic PRKN mutations…Suicidal Ideation and Behavior in Parkinson’s Disease: A Systematic Review and Meta-Analysis
Objective: Parkinson’s disease (PD) is a progressive neurodegenerative disorder that affects both motor and non-motor neurological functions. In addition to motor impairment, patients frequently experience…5-year Longitudinal Changes in Non-motor Symptoms and Their Association With Motor Progression in Parkinson’s Disease
Objective: To examine longitudinal relationships between non-motor symptoms (NMS) and motor progression in Parkinson’s disease (PD), and to determine whether baseline NMS predict motor decline…Physical Activity is Associated with Attenuated Motor and Cognitive Progression in Parkinson’s Disease
Objective: To determine whether physical activity (PA) modifies the rate of motor and cognitive progression in Parkinson’s disease (PD) and to identify specific components of…Impact of Alpha-Synuclein Burden and Cellular Stress on GBA-PD Macrophage
Objective: This study explores how non-neuronal dysfunction drives the rapid progression of GBA-PD, aiming to identify therapeutic targets that restore protein degradation and cellular stability.…Role of ApoE in α-Synuclein Pathology
Objective: To investigate whether apolipoprotein E (ApoE) isoforms directly interact with α-synuclein and determine how these interactions influence aggregation dynamics and cellular uptake. Background: The…Multi-Omics Analysis Reveals Brain and Biofluid Molecular Changes Induced by Chronic Sleep Fragmentation in a Prodromal Parkinson’s Disease Mouse Model
Objective: To investigate the molecular mechanisms by which chronic sleep fragmentation accelerates the progression of prodromal Parkinson’s disease (PD). Background: Recent epidemiological studies suggest that…Clinical impact of local field potential sensing–guided deep brain stimulation: a real‑world registry
Objective: To evaluate the association between Local Field Potential (LFP) sensing use and patient outcomes (EuroQol 5-Dimensions (EQ5D), medications), as well as device-related outcomes by…Longitudinal Changes and Clinical utility of the Neurological Pupillary Index in De Novo Parkinson’s Disease
Objective: To characterize longitudinal changes in pupillometric parameters in de novo Parkinson’s disease and explore their associations with clinical severity and disease progression. Background: Automated…STEM-PD: An open-label phase I/II trial of transplanted human pluripotent stem cell-derived dopaminergic progenitor cells in Parkinson’s disease
Objective: The STEM-PD trial evaluates safety, tolerability, and feasibility of intraputaminal transplantation of STEM-PD, a dopaminergic(DA) progenitor product derived from a clinical-grade human embryonic stem…
- « Previous Page
- 1
- …
- 106
- 107
- 108
- 109
- 110
- …
- 208
- Next Page »