Multiple System Atrophy-India (MSA-IND) Registry
Objective: To understand Multiple system atrophy (MSA) clinical phenotype from India. Background: There is paucity of data from underrepresented populations including India, regarding the clinical…The Allosteric Activator of Lysosomal Glucocerebrosidase VQ-101 Demonstrates Robust Evidence of Target and Pathway Engagement in People with Parkinson’s Disease: Results from a 6-Month Open-Label Extension Study
Objective: To evaluate the continued safety, pharmacokinetics (PK), and pharmacodynamics of VQ-101 in patients with Parkinson’s disease (PD) with and without a GBA1 mutation. Background:…Neurological Wilson’s disease: another form of tauopathies?
Objective: The authors would hope to identify distribution of Tau protein within the brain of Wilson's disease patients by tau-targeted positron emission tomography (PET) tracers Background:…Lipid Alterations in Central Nervous System and Plasma During Early Stages of Parkinson’s Disease
Objective: To identify early lipid alterations in a progressive mouse model of Parkinson’s disease (PD) and to determine whether peripheral lipid signatures reflect lipid changes…Molecular Profiling of Brain-Derived Extracellular Vesicles and Fluid Biomarkers in Parkinsonism: Distinct Signatures and Clinical Correlates in Progressive Supranuclear Palsy
Objective: (1) To validate serum-based enrichment of neuronal (L1CAM+) and microglial (TMEM119+) EVs in PSP; (2) to characterize α-synuclein, tau, and inflammatory/autophagic mediators in EVs…Beta and Gamma Local Field Potentials in Chronic Deep Brain Stimulation for Parkinson’s Disease: Programming Implications from a Systematic Review
Objective: To define distinct clinical roles of beta- and gamma-band local field potential (LFP) biomarkers in chronic deep brain stimulation (DBS) for Parkinson’s disease (PD)…Clustered Difference of Gut Microbiome in Helicobacter pylori-negative and positive Group Effect on Clinical Motor Symptoms in PD (Helicobacter pylori-Stool Microbiome or HP-SM Trial)
Objective: This study aims to evaluate the therapeutic effect of H.pylori eradication on clinical motor symptoms in PD and the association between gut microbiomes. Background: Previous…Feasibility and Preliminary Outcomes of an Online Fatigue Self Management Programme for People With Parkinsons Disease
Objective: To assess the feasibility, acceptability, and preliminary outcomes of an online fatigue self management programme for people with Parkinsons disease. Background: Fatigue is a…Developing a toolkit for the assessment and management of lower urinary tract symptoms in parkinsonism
Objective: To develop an easy to use toolkit that expedites the work-up and management of lower urinary tract symptoms (LUTS) in people with parkinsonism for…Integrated and Multidisciplinary Care for Older Adults with Parkinson’s Disease: A value-driven approach
Objective: To evaluate value driven outcomes of an integrated multidisciplinary Parkinson’s clinic for older adults in Singapore Background: Parkinson’s Disease (PD) is a complex neurodegenerative…
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