Sudomotor Dysfunction in Patients With Normal and Abnormal Cardiac MIBG
Objective: We examined the pattern of sweat loss in patients with normal versus abnormal MIBG and considered the implications of this in predicting phenoconversion trajectory.…Underestimation of Nighttime Sleep Symptoms in Isolated RBD is Associated with Increased Risk of Phenoconversion to Synucleinopathy: A North American Prodromal Synucleinopathy Consortium Study
Objective: To determine whether mismatch between participant (PT) self-perceived and bed partner (BP)–reported sleep symptoms is associated with risk of phenoconversion to synucleinopathy. Background: Patients…7 Tesla MRI with Quantitative Susceptibility Mapping: Quantitative focal measurements and qualitative grading of the substantia nigra as a biomarker for Parkinson’s Disease
Objective: To quantitatively and qualitatively evaluate susceptibility changes in the dorsal SN (dSN), using quantitative susceptibility mapping (QSM) and susceptibility-weighted imaging (SWI) at 7Tesla (7T)…Probabilistic Mapping of Subthalamic Beta and Theta Subcircuits Reveals Segregated Connectivity and Deep Brain Stimulation Outcomes in Parkinson’s Disease
Objective: To map theta- and beta-band activity within the subthalamic nucleus (STN) and examine associations with motor improvement and impulsive behavior in Parkinson’s disease (PD)…Beyond α-Synuclein SAA: A Multimodal Minimally Invasive Platform for Biologically Informed Diagnosis of Parkinsonian Syndromes
Objective: To evaluate whether integrating dermal α-synuclein and 4R-tau seed amplification assays (SAAs) with serum neurofilament light chain (NfL) improves diagnostic precision in neurodegenerative parkinsonian…Cerebellar Network Compensation in Parkinson’s Disease: Functional Connectivity Across Motor and Cognitive Circuits
Objective: To investigate whether alterations in cerebellar connectivity with cortical and basal ganglia networks in Parkinson’s disease (PD) represent compensatory network adaptations related to dopaminergic…Epidemiology of Parkinson’s Disease and Parkinsonism in Kazakhstan from 2015 to 2024 based on National Health Data
Objective: To evaluate the prevalence and dynamics of Parkinson’s disease and parkinsonian syndromes in the population of Kazakhstan from 2015 to 2024 using data from…Beyond Diagnosis: Putaminal ADC Hyperintensity and Infratentorial Signs Reflect Motor Severity in MSA
Objective: To clarify the clinical significance of neuroimaging markers in multiple system atrophy (MSA) by (1) examining concordance among putaminal MRI markers across sequences, (2)…When Muscles Relax but Symptoms Persist: A Case of Dysfunctional Sensory-Motor Cortical Integration in Botulinum Toxin-Resistant Blepharospasm
Objective: To present a case of blepharospasm (BSP) with objective response to serial botulinum toxin injections but persistent subjective symptoms, highlighting the role of sensory…MDS Guidance Framework for Electronic Clinical Outcome Assessments: Updating Practices for Validation and Implementation
Objective: To present the draft International Parkinson and Movement Disorder Society (MDS) guidance framework for validating, evaluating, and implementing electronic clinical outcome assessments (eCOAs). Background:…
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