MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

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Articles tagged "Acetylcholine"

  • 2024 International Congress

    Cholinergic Basal Forebrain Integrity and Cognition in Parkinson’s Disease

    N. Slater, T. Melzer, D. Myall, G. Hall-Mcmaster, A. Harris, K-L. Horne, T. Anderson, J. Dalrymple-Alford (Christchurch, New Zealand)

    Objective: To examine the association between the integrity of the cholinergic basal forebrain (cBF) and cognition in Parkinson’s disease (PD). Background: Most PD patients experience…
  • 2024 International Congress

    Inflammation Biomarkers and Free Water Fraction in the Cholinergic Forebrain System in Idiopathic Parkinson’s Disease

    S. Crowley, P. Kanel, S. Roytman, B. Hampstead, N. Bohnen (Charelston, USA)

    Objective: Investigate if inflammatory biomarkers moderate the association between, cholinergic basal forebrain free water fraction and cholinergic innervation in idiopathic Parkinson’s disease. Background: The cholinergic…
  • 2024 International Congress

    Mapping Cholinergic Signaling in Parkinson Disease Using [18F]VAT

    J. O'Donnell, M. Campbell, S. Norris, B. Maiti, A. Soda, S. Moerlein, Z. Tu, J. Perlmutter (St. Louis, USA)

    Objective: To determine how cholinergic signaling changes within Parkinson Disease (PD) and how these differences relate to the progression of cognitive and behavioral symptoms. Background:…
  • 2023 International Congress

    Hesperidin ameliorates rotenone-induced Parkinson’s disease in mice via improving neuroinflammation and oxidative stress

    D. Singh (Prayagraj, India)

    Objective: The goal of the present study is to examine the neuroprotective property of hesperidin on rotenone-induced Parkinson's disease in mice. Background: The second most…
  • 2023 International Congress

    Cholinergic topography and clinical profile of early Parkinson’s patients with GBA mutations

    S. Slingerland, S. Vander Zee, G. Carli, A. Slomp, J. Boertien, T. van Laar (Groningen, Netherlands)

    Objective: To explore the regional cholinergic innervation and clinical profile of early Parkinson’s disease (PD) patients carrying GBA mutations (GBA-PD). Background: The most common genetic…
  • 2023 International Congress

    Topography of cholinergic vulnerability correlates of PIGD motor deficits in DLB and PSP: A [18F]-FEOBV PET study

    P. Kanel, T. Brown, S. Roytman, J. Barr, C C. Spears, N. Bohnen (Ann Arbor, USA)

    Objective: To understand the relationship between cholinergic vulnerability and Postural Instability and Gait Disturbances (PIGD) motor features in dementia with Lewy bodies (DLB), and progressive…
  • 2023 International Congress

    Microbiota and Gastrointestinal Manifestations of Parkinson’s Disease with Arabic Translation of Gastrointestinal Dysfunction Scale

    Y. Salah, N. Dawood, M. Salama, A. Shalash (cairo, Egypt)

    Objective: To investigate the frequency of occurrence of gastrointestinal tract GIT symptoms and their relation to patients’ clinical characteristics in addition the characteristics of gut…
  • 2023 International Congress

    Cholinergic deficits in Parkinson Disease

    R. Miller, D. Dhavale, J. O’Shea, E. Franklin, N. Cairns, R. Perrin, M. Campbell, J. Perlmutter, P. Kotzbauer (St. Louis, USA)

    Objective: To determine whether loss of cholinergic projections to cortical and limbic regions contributes to the development of dementia in Parkinson’s disease (PD). Background: PD…
  • 2023 International Congress

    Cholinergic subtyping in Parkinson disease: differential 2-year interval changes

    N. Bohnen, S. Roytman, T. Brown, K. Frey, P. Scott, R. Koeppe, R. Albin, P. Kanel (Ann Arbor, USA)

    Objective: To investigate 2-yr interval change in cholinergic transporters in biology-based cholinergic subgroups using serial VAChT [18F]FEOBV brain PET in Parkinson’s disease (PD). Background: Current…
  • 2023 International Congress

    Free water imaging of the cholinergic forebrain in body vs. brain-first Parkinson’s disease subtypes

    S. Roytman, Y. Ota, T. Brown, P. Scott, R. Albin, P. Kanel, N. Bohnen (Ann Arbor, USA)

    Objective: To investigate the relationship between basal forebrain (BF) neurodegeneration and cholinergic system in body vs brain-first Parkinson’s disease (PD) subtypes. Background: Free water imaging…
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