Mapping Cholinergic Signaling in Parkinson Disease Using [18F]VAT
Objective: To determine how cholinergic signaling changes within Parkinson Disease (PD) and how these differences relate to the progression of cognitive and behavioral symptoms. Background:…Chronic striatal cholinergic agonist infusion as a model of dystonia
Objective: The objectives of this work were to create a primate model of dystonia based on striatal infusion of a muscarinic agonist (oxotremorin), and to…Altered [18F]VAT Uptake Supports Cholinergic Dysfunction in Isolated Adult-Onset Cervical Dystonia
Objective: Our aim is to investigate whether altered cholinergic function is associated with isolated adult-onset cervical dystonia (CD). Background: Animal models and clinical observations suggest…The comparison of curcumin and naringenin effects on motor function in rotenone model of Parkinson’s disease
Objective: The aim of the study was to compare the effects of curcumin and naringenin on rotenone-induced motor deficits and related neurochemical changes. Background: Experimental…The development of a multiplex allele specific PCR to improve the diagnostic yield of NGS in the GBA gene screening
Objective: Our aim is to offer a complete and reliable diagnostic service excluding false negative. Background: Heterozygous variants in the GBA gene are the most…Nucleus basalis of Meynert and total gray matter atrophy are related to cognitive and gait decline in Parkinson’s disease
Objective: To assess the associations between the nucleus basalis of Meynert (NBM) and total grey matter atrophy with cognitive phenotype and gait measures in a…Hesperidin ameliorates rotenone-induced Parkinson’s disease in mice via improving neuroinflammation and oxidative stress
Objective: The goal of the present study is to examine the neuroprotective property of hesperidin on rotenone-induced Parkinson's disease in mice. Background: The second most…Cholinergic topography and clinical profile of early Parkinson’s patients with GBA mutations
Objective: To explore the regional cholinergic innervation and clinical profile of early Parkinson’s disease (PD) patients carrying GBA mutations (GBA-PD). Background: The most common genetic…Topography of cholinergic vulnerability correlates of PIGD motor deficits in DLB and PSP: A [18F]-FEOBV PET study
Objective: To understand the relationship between cholinergic vulnerability and Postural Instability and Gait Disturbances (PIGD) motor features in dementia with Lewy bodies (DLB), and progressive…Microbiota and Gastrointestinal Manifestations of Parkinson’s Disease with Arabic Translation of Gastrointestinal Dysfunction Scale
Objective: To investigate the frequency of occurrence of gastrointestinal tract GIT symptoms and their relation to patients’ clinical characteristics in addition the characteristics of gut…
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