Mapping Cholinergic Signaling in Parkinson Disease Using [18F]VAT
Objective: To determine how cholinergic signaling changes within Parkinson Disease (PD) and how these differences relate to the progression of cognitive and behavioral symptoms. Background:…Chronic striatal cholinergic agonist infusion as a model of dystonia
Objective: The objectives of this work were to create a primate model of dystonia based on striatal infusion of a muscarinic agonist (oxotremorin), and to…Altered [18F]VAT Uptake Supports Cholinergic Dysfunction in Isolated Adult-Onset Cervical Dystonia
Objective: Our aim is to investigate whether altered cholinergic function is associated with isolated adult-onset cervical dystonia (CD). Background: Animal models and clinical observations suggest…Cholinergic denervation is more severe in patients with Parkinson disease compared to Progressive Supranuclear Palsy-Parkinsonism subtype: A [18F]-FEOBV PET study
Objective: : To investigate cholinergic brain regional differences between Progressive supranuclear palsy with parkinsonism (PSP-P) and Parkinson's disease (PD), using the highly selective radiotracer for…Increased cholinergic activity in specific brain regions associated with the presence of dyskinesias in Parkinson’s disease: A [18F]-FEOBV PET study
Objective: To explore the role of cholinergic dysfunction in dyskinesia symptoms in people with Parkinson’s disease (PD). Background: Dyskinesias, involuntary and sometimes excessive or uncontrolled…Cholinergic Brain Signature of Presbyvestibulopathy in Parkinson’s Disease: Exploring Central Nervous System Vestibular Mechanisms
Objective: To investigate topographic cholinergic brain differences between Parkinson's disease (PD) patients with and without presbyvestibulopathy (PVP). Background: Age-associated vestibulopathy (PVP) is commonly observed in…Ibudilast, a Phosphodiesterase Inhibitor, Alleviates Huntington’s Disease Pathology through Neuroinflammation Modulation and Signaling Pathway Regulation in a Rat Model
Objective: This research aims to assess whether Ibudilast (IBD), a phosphodiesterase IV (PDE IV) inhibitor, can mitigate the damage induced by 3-nitropropionic acid (3-NP) in…Early GBA-Related Parkinson’s Disease has a Distinct Clinical Phenotype and Cholinergic Innervation
Objective: This study aims to characterize the clinical features and cholinergic innervation of early Parkinson’s disease (PD) patients with GBA mutations (GBA-PD). Background: The GBA-PD…Cholinergic brain vulnerabilities associate with diabetic comorbidity in Parkinson disease
Objective: We aim to explore differences in brain cholinergic nerve terminal integrity between Parkinson's disease (PD) patients with and without comorbid diabetes, utilizing a highly…Cholinergic Basal Forebrain Integrity and Cognition in Parkinson’s Disease
Objective: To examine the association between the integrity of the cholinergic basal forebrain (cBF) and cognition in Parkinson’s disease (PD). Background: Most PD patients experience…
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