Brain Cholinergic Changes in Progressive supranuclear palsy: A single-subject voxel-wise approach to understanding heterogeneity
Objective: To characterize individual-level topographical patterns of cholinergic changes compared to controls in Progressive Supranuclear Palsy (PSP) using a voxel-wise approach. Background: The cholinergic system…Topographical heterogeneity of cholinergic system status in Multiple System Atrophy: A series report
Objective: To characterize individual-level topographical patterns of cholinergic upregulation and downregulation in Multiple System Atrophy (MSA) using a whole brain voxel-wise approach. Background: MSA is…Case report and Literature Review on Atypical Parkinson’s Disease
Objective: Atypical parkinsonism is classified as a subgroup of Progressive neurodegenerative diseases, characterized by symptoms of Parkinson's disease. Background: Progressive supra nuclear palsy of the…The Cholinergic System in Cervical Dystonia – An [18F]-FEOBV PET study
Objective: To investigate presynaptic cholinergic functioning in cervical dystonia (CD) by comparing [18F]-FEOBV binding in patients and controls, as well as exploring correlations with motor…Rare Phenomenology with Nicotinic Ganglionic Acetylcholine Receptor Antibodies
Objective: Autoimmune dysautonomia has been described in patients with positive nicotinic ganglionic (alpha-3) acetylcholine receptor antibodies (α3-AchR Ab). We present a case of myoclonus in…The Effectiveness of Rivastigmine in Parkinson’s Disease: Impact on Motor Symptoms, Gait, Cognitive Function, and Falls – A Systematic Review and Meta-Analysis of Double-Blind, Placebo-Controlled RCTs
Objective: To evaluate the efficacy of rivastigmine in patients with Parkinson’s disease (PD) by assessing its impact on motor symptoms, cognitive function, gait, falls, and…Decreased cholinergic activity in specific brain regions associated with slower lower limb visual choice reaction time in Parkinson’s disease: A [18F]-FEOBV PET study
Objective: To investigate the relationship between cholinergic system changes, as measured by vesicular acetylcholine transporters (VAChT) [18F] fluoroethoxybenzovesamicol ([18F] FEOBV) binding in PET, and cognitive performance, measured as…Impaired Speech Perception in Noise (SPiN), Hearing Loss, and Cholinergic Denervation in Parkinson’s Disease
Objective: This study will investigate the relationships among speech-perception-in-noise (SPiN), hearing acuity, and cholinergic system changes in patients with PD. Background: Recent studies highlight a…The Role of α7 Nicotinic Acetylcholine Receptor in Mitochondrial Homeostasis and Neuroprotection
Objective: This study aims to explore the neuroprotective role of α7 nicotinic acetylcholine receptor (α7nAChR) in mitochondrial homeostasis and its potential as a therapeutic target…Striatal dopamine- and basal forebrain cholinergic-dependent brain metabolism and cognition in Parkinson’s disease
Objective: To explore the interrelation of striatal dopamine, cholinergic basal forebrain volume, brain metabolism, and cognition in PD. Background: Parkinson’s disease (PD) involves multiple neurotransmitter…
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