Early cognitive impairment is associated with specific regional cholinergic denervation in Parkinson’s disease
Objective: To evaluate regional cholinergic correlates of cognitive impairment in newly diagnosed, treatment-naïve Parkinson’s disease (PD) patients. Background: Mild cognitive impairment (PD-MCI) is a common…Clinical and neurological features of the course of parkinsonism in the presence of chronic renal disease
Objective: To study the clinical and neurological features of the course of parkinsonism in chronic renal disease. Background: Under our supervision were 30 patients with…Donepezil for mild cognitive impairment in Parkinson’s disease: A 48-week follow-up study
Objective: To investigate the efficacy of donepezil for mild cognitive impairment (MCI) in Parkinson’s disease (PD). Background: MCI is common in PD. The mechanism of…Neuroprotective and neurotrophic efficacy of Ginkgo biloba extracts against 3-nitropropionic acid-induced oxidative stress in a rat model of Huntington’s disease
Objective: The present study examined the potential neuroprotective and neurotrophic efficacy of GBE against 3-nitropropionic acid (3-NP)-induced oxidative stress in a rat model of HD…Contribution of pedunculopontine nucleus cholinergic neurons to L-DOPA-induced dyskinesia and PD motor deficits in hemi-parkinsonian rats
Objective: To determine if chemogenetic and pharmacological modulation of pedunculopontine nucleus (PPN) cholinergic neurons can alter L-DOPA-induced dyskinesia and gait deficits in hemi-parkinsonian rats. Background:…Role of APOE ε4 status and Sex on Somatosensory Integration and Dual-Task Cost in Parkinson’s disease
Objective: To determine whether ε4 status relates to impaired somatosensory integration deficits in males more than females in people with Parkinson’s disease (PwPD). Background: Previous…A case of donepezil-induced multifocal myoclonus
Objective: To describe the case of a patient who developed severe multifocal myoclonus due to donepezil. Background: Donepezil is a cholinesterase inhibitor frequently used to…Low doses of scopolamine exacerbates dementia among Drosophila with Parkinson’s disease pathophysiology
Objective: To assess the non-inducing doses of scopolamine (SCL) on the memory function of Drosophila previously induced with Parkinson's disease phenotype. Background: A large body…The interplay between cholinergic activity, attention, and turning in Parkinson’s disease
Objective: Explore how cholinergic activity (measured by short latency afferent inhibition [SAI]) and attention relate to quality of turning performance over a week of daily…Deceleration capacity of heart rate: is cardiac vagal modulation impaired in idiopathic Parkinson’s disease?
Objective: Assessment of cardiac vagal modulation through the analysis of heart rate deceleration capacity (DC) in idiopathic Parkinson’s disease (PD). Background: Cardiac autonomic dysfunction manifests…
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