Neuropsychiatric Symptom Evolution Over the First Decade of Biomarker-Defined Parkinson’s Disease
Objective: To examine the evolution of neuropsychiatric symptoms (NPS) in biomarker-defined Parkinson’s disease over the first decade following diagnosis. Background: Parkinson’s disease (PD) is frequently…Impact of Alpha-Synuclein Burden and Cellular Stress on GBA-PD Macrophage
Objective: This study explores how non-neuronal dysfunction drives the rapid progression of GBA-PD, aiming to identify therapeutic targets that restore protein degradation and cellular stability.…Longitudinal α-synuclein Seed Amplification Assay Analysis of PPMI Participants
Objective: To evaluate longitudinal consistency in the assessment of misfolded α-synuclein aggregates (syn-seeds) in cerebrospinal fluid (CSF) by α-synuclein seed amplification assay (synSAA). Background: synSAA…Novel Modeling Approach for Comparing Treatment-Naive and Post-Treatment Neuronal Synucleinopathy Progression Using Multi-Modal PPMI Data
Objective: To characterize multi-domain progression over the course of Neuronal alpha-Synuclein Disease (NSD), in both treatment-naive and treated individuals. Background: Neuronal alpha-Synuclein Disease (NSD), a…Urine-derived neuronal extracellular vesicle α-synuclein seed amplification assay for synucleinopathies: a non-invasive biomarker study
Objective: To investigate whether pathogenic α-synuclein can be detected using real-time quaking-induced conversion (RT-QuIC) in urine-derived neuronal extracellular vesicles (NEVs) as a fully non-invasive biomarker…Molecular Profiling of Brain-Derived Extracellular Vesicles and Fluid Biomarkers in Parkinsonism: Distinct Signatures and Clinical Correlates in Progressive Supranuclear Palsy
Objective: (1) To validate serum-based enrichment of neuronal (L1CAM+) and microglial (TMEM119+) EVs in PSP; (2) to characterize α-synuclein, tau, and inflammatory/autophagic mediators in EVs…Seed Amplification Assay Is More Sensitive To Detecting α-Synuclein In Gut Biopsies Than Immunohistochemistry
Objective: Assess seed amplification assay (SAA) and immunohistochemistry (IHC) in peripheral gut mucosal biospecimens as PD diagnostics. Background: SAA detects misfolded alpha-synuclein (α-syn) aggregates across…Role of ApoE in α-Synuclein Pathology
Objective: To investigate whether apolipoprotein E (ApoE) isoforms directly interact with α-synuclein and determine how these interactions influence aggregation dynamics and cellular uptake. Background: The…Differential Microglial Activation and p-Ser129 Alpha-Synuclein Induction by Neurotropic and Non-Neurotropic Influenza A Virus Strains
Objective: To compare the innate immune responses and neurodegenerative marker induction in human microglia following infection with neurotropic vs. non-neurotropic Influenza A virus (IAV) under…Unraveling Kinase-Phosphatase Dysregulation in Parkinson’s disease Peripheral Blood Mononuclear Cells Through Targeted Transcript Analysis
Objective: To probe kinase-phosphatase dysregulation and peripheral biomarker potential in peripheral blood mononuclear cells (PBMCs) via LRRK2 (kinase), PPM1H and PP2A (phosphatases), LC3 (autophagy), and…
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