Neutrophil Extracellular Traps Reveal Novel Inflammatory Signatures in Parkinson’s Disease and Multiple System Atrophy
Objective: This cross-sectional study investigates neutrophil extracellular trap (NET) activation in Parkinson’s disease (PD) and multiple system atrophy (MSA) by quantifying plasma levels of NET-associated…Impact of Skin Biopsy Detection of Phosphorylated Alpha-Synuclein and its Distribution Patterns on the Diagnosis of Synucleinopathies
Objective: To assess how skin biopsy detection of phosphorylated alpha-synuclein (P-SYN) and its distribution pattern impact the diagnosis of synucleinopathies, such as Parkinson’s disease (PD),…Lewy Pathology correlates with neuroinflammation in the hippocampus of Synucleinopathy patients in a subregion specific manner
Objective: The objective of this study is to examine the sub-regional differences in neuroinflammation (NI) in response to Lewy pathology (LP) within the hippocampus of…Targeted Brain Delivery of Rifampicin via PEG-PLA Nanoparticles: A Promising Therapeutic Strategy for Neuroprotection and Disease Modification in Parkinsonian Mouse Models
Objective: This study aimed to design and validate a nanoparticle-based delivery system for rifampicin, with the objective of enhancing its therapeutic efficacy, improving brain targeting,…Cerebrospinal fluid measured α-synuclein is related to metabolite profile in the serum and CSF
Objective: Determine metabolites associated with cerebrospinal fluid (CSF) measured α-synuclein (α-syn) using untargeted metabolomics measured in the serum and CSF. Background: Several large studies have…Blood-based biomarkers for diagnosis and prediction of Parkinson’s Disease in GBA1 individuals
Objective: To investigate glucocerebrosidase (GCase) enzymatic activity and different forms of α-synuclein (aggregated -Asyna – and monomeric - Asynm) in peripheral blood mononuclear cells (PBMCs)…Early Indicators of Alpha-synuclein Aggregation: Can Autonomic and Cognitive Markers Predict Prodromal Parkinson’s Disease?
Objective: To develop a model that predicts alpha synuclein (a-syn) status of patients at risk of Parkinson’s disease (PD) using non-motor and cognitive tests that…Effect of Aβ on α-synuclein propagation
Objective: To investigate how amyloid-beta (Aβ) pathology affects α-synuclein (α-syn) propagation. Background: Lewy bodies, the pathological hallmark of Parkinson’s disease and dementia with Lewy bodies,…Hyperbaric Oxygen Therapy for Parkinson’s disease via modulation of gut microbiota
Objective: To investigate the effect of hyperbaric oxygen therapy (HBOT) on gut microbiota in a preclinical model of PD. Background: Humans have coevolved with complex…Alpha-Synuclein Aggregates in the Olfactory Epithelium of Subjects with Parkinson Disease, Dementia, COVID-19, and in Aged Controls
Objective: We sought to examine whether neuroepithelial structures of the nasal cavity differ between individuals diagnosed with a Lewy body disorder vs those with COVID19…
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