Motor onset of Parkinsonʼs disease: Is there a somatotopic pattern?
Objective: To study the clinical onset and progression of motor manifestations in different body regions in early PD patients. Background: The vulnerability of the nigrostriatal…Quantifying movement to measure Parkinson’s Disease severity and progression in a Phase 2 Study (SPARK)
Objective: To develop and evaluate objective measures of Parkinson’s disease (PD) severity and progression by applying dynamical systems analysis to inertial sensor kinematic data. Background:…Application of PKG System for Objective Measurement and Early Identification in Parkinson’s Disease
Objective: This study aimed to assess the correlations of the PKG data with clinical scores of bradykinesia, rigidity and tremor. Background: The treatment of levodopa…Passive monitored daily motor behavior significantly relates to quality of life in early Parkinson’s disease
Objective: To investigate whether passively acquired measures of gait and hand gestures are associated with health-related quality of life (HrQoL; PDQ-39) and health-state (EQ-5D-5L) in…Improving estimation of Parkinson’s disease risk – enhancing the PREDICT-PD algorithm
Objective: To develop and test an enhanced algorithm for the prediction of Parkinson’s disease (PD) risk. Background: The PREDICT-PD algorithm estimates risk of PD using…Ceftriaxone improves motor function in a rat hemi-parkinsonian model: Potential to delay bilateral progression of motor deficits in Parkinson’s disease
Objective: This study sought to evaluate the impact of ceftriaxone, as a potential repurposed drug, in ameliorating motor decline in a unilateral rat 6-hydroxydopamine (6-OHDA)…Emerging motor dysfunction in those at-risk of Parkinson’s disease: 5-year follow-up of PREDICT-PD participants
Objective: To determine how motor features emerge over time in individuals estimated to be at higher risk of Parkinson’s disease (PD), compared with lower risk…Personal Kinetigraph and Deep Brain Stimulation with Parkinson’s Disease
Objective: To better understand the utility of a wearable wrist sensor in assessing and managing motor fluctuations in a population of patients with advanced Parkinson…Kinematic assessment of bradykinesia in patients with amyotrophic lateral sclerosis
Objective: To kinematically assess abnormalities of voluntary upper limbs movements in patients with amyotrophic lateral sclerosis compared to healthy subjects. To investigate possible relationships between…Movement Disorders Analysis Using a Deep Learning Approach
Objective: Using a deep learning inspired approach, we developed a tool to compute an objective score of bradykinesia. Background: Bradykinesia is defined as a motor…
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