Objective: To determine how motor features emerge over time in individuals estimated to be at higher risk of Parkinson’s disease (PD), compared with lower risk participants in the PREDICT-PD study.
Background: The PREDICT-PD study aims to stratify older people in the UK general population and identify those at higher risk of future Parkinson’s disease (PD) using a web-based assessment and an evidence-based risk algorithm (1). The higher risk group was defined as individuals above the 15th centile of risk estimates (odds cut off 1:33). At baseline, the higher risk group showed worse motor scores when compared with the lower risk group (2).
Method: The clinical assessment used the motor score of MDS-UPDRS (part III) in individuals who had been stratified for risk of PD after completing online testing. The higher risk and lower risk group were compared for their change in MDS-UPDRS part III scores between baseline and a follow-up assessment after a minimum of 5 years.
Results: Ninety-eight subjects were included (47 females, 74.5yo, SD: 5.2y). Higher risk subjects had a significantly higher median change in UPDRS part III scores (7.04, IQR 1–9) than lower risk subjects (1.3, IQR -1–3.0; p<0.0001). During this time, two of the higher risk participants received a PD diagnosis, and demonstrated subtle motor signs 2 and 5 years before receiving the diagnosis.
Conclusion: This study identifies the common motor prodromes and their evolution during the pre-diagnostic phase of Parkinson’s disease.
References: (1) Noyce, A. J., Bestwick, J. P., Silveira-Moriyama, L., Hawkes, C. H., Knowles, C. H., Hardy, J., … & Schrag, A. (2014). PREDICT-PD: Identifying risk of Parkinson’s disease in the community: methods and baseline results. J Neurol Neurosurg Psychiatry, 85(1), 31-37. (2) Noyce, A. J., Schrag, A., Masters, J. M., Bestwick, J. P., Giovannoni, G., & Lees, A. J. (2017). Subtle motor disturbances in PREDICT-PD participants. Journal of Neurology, Neurosurgery & Psychiatry, 88(3), 212-217.
To cite this abstract in AMA style:C. Simonet, A. Schrag, J. Bestwick, A. Lees, A. Noyce. Emerging motor dysfunction in those at-risk of Parkinson’s disease: 5-year follow-up of PREDICT-PD participants [abstract]. Mov Disord. 2020; 35 (suppl 1). https://www.mdsabstracts.org/abstract/emerging-motor-dysfunction-in-those-at-risk-of-parkinsons-disease-5-year-follow-up-of-predict-pd-participants/. Accessed December 1, 2023.
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