Can digital Mobility Outcomes differentiate cognitive impairment in Parkinson’s Disease?
Objective: To determine if digital mobility outcomes (DMOs) differentiate between those with and without cognitive impairment in Parkinson’s disease (PD). Background: Cognitive impairment is common…Cognitive Safety and Stability in DBS for Parkinson’s Disease: Evidence for the Inclusion of Patients with Baseline Mild Cognitive Impairment.
Objective: Investigate the cognitive safety of Deep Brain Stimulation (DBS) in PD patients with baseline pre-operative diagnosis of Mild Cognitive Impairment (MCI) Background: DBS is…Early Caudate Dopaminergic Loss as an Imaging Biomarker of Cognitive Impairment in Parkinson’s Disease: A Longitudinal Analysis
Objective: The primary objective was to determine whether early pre-synaptic caudate denervation, measured using 123 I ioflupane SPECT quantitative metrics, provides independent and incremental prognostic value…Subregional Striatal Dopaminergic Deficits, Cerebral Hypoperfusion and Cognitive Impairment in Parkinson’s Disease
Objective: To investigate the associations of subregional striatal dopaminergic deficits with regional cerebral blood flow (CBF) and cognitive impairment in patients with Parkinson’s disease (PD).…Association of Coffee Consumption and Smoking with Cognitive Function in Patients with Early Parkinson’s Disease
Objective: This study investigated cognitive differences among patients with early-stage Parkinson's disease (PD) according to coffee consumption and smoking status. Background: PD is frequently accompanied…Sex-Specific Associations of APOE ε4 with Cognitive Decline in Parkinson’s Disease: Insights from the Critical Path Institute GEM-PD Initiative
Objective: We aim to advance precision medicine strategies for Parkinson’s disease (PD) through data-driven research led by the Critical Path for Parkinson’s (CPP) global public-private…Multimodal Immune Biomarkers of Parkinson’s Disease Progression
Objective: To determine the longitudinal relationship between immune parameters and Parkinson’s progression; and immune predictors of motor and cognitive milestones. Background: PD progression is highly…Effect of ApoE ε4 allele on brain metabolism and cognition in non-demented Parkinson’s disease
Objective: This study aimed to explore the interplay between Apolipoprotein E (ApoE) ε4 allele, brain metabolism, and cognition in non-demented Parkinson’s disease (PD) patients. Background:…Remotely acquired speech-based biomarkers and their relation to motor and cognitive functions in Parkinson’s disease
Objective: To evaluate the feasibility and clinical validity of remote, digital speech-based cognitive and speech motor assessments in Parkinson’s disease (PD). Background: Speech in PD…Freezing of Gait in Atypical Parkinsonism improves with Transcranial Direct Current Stimulation
Objective: To report improvement in freezing of gait following unilateral transcranial direct current stimulation in a patient with with atypical parkinsonism and severe freezing of…
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