Transcriptomic and Proteomic Profiling for Effective Deep Brain Stimulation in Parkinson’s Disease
Objective: To determine whether transcriptomic and proteomic changes predict better motor outcomes after deep brain stimulation (DBS) surgery in Parkinson’s disease (PD). Background: DBS is…Unveiling the Long-term Impact of Unilateral Vim DBS in Essential Tremor
Objective: Our aim is to evaluate the long-term benefit of unilateral VIM DBS. Background: Essential tremor (ET) is the most common movement disorder, and in…Understanding the Neurochemical Basis of STN and GPi-DBS: A Human Microdialysis Study
Objective: Analyze the extracellular concentrations of GABA and glutamate in response to acute electrical stimulation during DBS surgery using samples obtained from STN, thalamus, GPi…Deposition of phosphorylated TDP-43 around the tip of deep brain stimulation leads
Objective: The objective of this study is to investigate the depositions of abnormal proteins, including phosphorylated tau (p-tau) and phosphorylated transactivation response DNA-binding protein of…Effect of Target Selection on Mood, Pain, and Medications after DBS in PD
Objective: To describe the association between medication adjustments with mood and pain following bilateral deep brain stimulation (DBS) in Parkinson’s disease (PD). Background: Depression, anxiety,…Development of a Beta-sensing Pathway in Deep brain stimulation to optimise utility of Local field potential recordings using the Percept system. (Newcastle Beta-sensing Algorithm – NBA)
Objective: To establish a pathway for utilisation of beta-sensing using the Percept technology which is applicable to real world clinical practice and optimises the utility…Effective Management of Generalized Dystonia with Unilateral Deep Brain Stimulation – Killing Two Birds with One Stone?
Objective: Managing generalized dystonia in adults is challenging despite pharmacological interventions due to suboptimal response or intolerable side effects. While bilateral Globus Pallidus internus Deep…Movement-Related Potentials Recorded Using Cerebellar Deep Brain Stimulation Leads
Objective: Investigate cerebellar local field potentials (LFPs) associated with movement using DBS leads in patients with spinocerebellar ataxia. Background: The Bereitschaftspotential (BP) detectable via EEG…Deep Brain Stimulators in Parkinson`s subthalamic nucleus: A Study of Decade Follow-Up
Objective: To analyze the motoric and non-motoric symptoms of Parkinson`s following subthalamic-nuclei deep brain stimulations from a decade of follow-up study. Background: From the rudiment…Personality of Parkinson’s disease patients may influence the development and evolution of non-motor fluctuations
Objective: to evaluate the impact of personality on non-motor fluctuations (NMFs) in Parkinson’s disease (PD) and on NMFs evolution after dopaminergic treatments or deep brain…
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