Data-driven Trajectories of Atrophy Explain Clinical Heterogeneity Across Lewy Body Diseases
Objective: To identify data-driven spatiotemporal trajectories of brain atrophy across the Lewy body disease spectrum and establish their relationship to clinical heterogeneity, core symptom profiles,…Nigrostriatal Dopaminergic Patterns in Dementia with Lewy Bodies and Parkinson’s Disease Subtypes: A DAT-SPECT Study within the SOC Framework
Objective: To determine whether the pattern of nigrostriatal dopaminergic degeneration in DLB mirrors that of “body-first” PD using DAT-SPECT imaging. Background: Dementia with Lewy bodies…Sex Differences for Primary Psychiatric Diagnoses and Associated Care Outcomes in Dementia with Lewy Bodies using Epic Cosmos
Objective: Assess sex differences for documented primary psychiatric diagnoses in people with dementia with Lewy bodies (DLB) and their associations with care outcomes (hospitalization, specialty…A Diffusion MRI Neurodegeneration Index for Lewy Body Dementia & Alzheimer’s disease
Objective: To develop a diffusion MRI-based neurodegeneration index using free-water imaging and assess its ability to quantify neurodegenerative burden in Lewy body dementia (LBD) and…Regional Distribution and Concordance of Structural MRI and 18F-FDG PET/MRI Findings in Parkinson-Plus Syndromes
Objective: The aim of this study was to evaluate the brain magnetic resonance imaging (MRI) findings and 18F-FDG positron emission tomography/magnetic resonance imaging (PET/MRI) hypometabolism…Self-Efficacy in Lewy Body Dementia Family Caregivers Is Associated with Better Sleep Quality and Social Support, and Lower Depression, Loneliness, and Strain
Objective: Examine the association of perceived self-efficacy in symptom management and community support service use with physical, psychological, and social well-being of Lewy Body Dementia…Latent Clinical States and Longitudinal Transitions in Prodromal Lewy Body Disease: A Data-Driven Analysis from the NaT-PROBE Study
Objective: To elucidate the structure of clinical heterogeneity and longitudinal transition patterns in a prodromal Lewy body disease (LBD) screening cohort using a data-driven approach.…Human Snca Knock-In Mouse as a Model for Synucleinopathy Research
Objective: Inter-species differences between mouse and human α-synuclein (asyn) may influence aggregation and pathology in animal models, highlighting the need for models expressing human asyn.…Emergence of Cortical Amyloid from the Prodromal Stage of the Lewy Body Disease Spectrum: Evidence from a PiB-PET Study
Objective: To characterize β-amyloid (Aβ) deposition across the Lewy body disease (LBD) spectrum using Pittsburgh compound B positron emission tomography (PiB-PET) and examine the influence…Progressive Dynamic Functional Network Disorganisation and its Association with Phenoconversion in Isolated REM Sleep Behaviour Disorder: A Multicentre Study
Objective: To characterise static and dynamic functional connectivity signatures of disease progression and phenoconversion in a multicentre longitudinal cohort of individuals with isolated REM sleep…
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