A novel pro-drug overcomes short-half life and absorption challenges and increase brain penetration of dopamine as a potential therapy for Parkinson’s disease
Objective: We developed a new small molecule drug candidate that would increase the effectiveness of dopamine delivery to the brain. We also sought to mitigate…Cortical–Subcortical Structural Signature of dementia with lewy bodies Reveals Cognitive Trajectories of Lewy Body Disease in REM Sleep Behavior Disorder
Objective: We aimed to derive a DLB-related structural MRI pattern based on cortical and subcortical morphometry and investigate whether this pattern predicts phenoconversion and clinical…Amyloid Burden in the Precuneus and Posterior Cingulate Gyrus Is Associated With Cognitive Function and White Matter Microstructure in Lewy Body Dementia
Objective: To investigate the relationship between amyloid burden measured by PET and white matter microstructural alterations assessed by advanced diffusion MRI in individuals with Parkinson’s…The Syn-D Study: Detection of Longitudinal Changes in Cutaneous Phosphorylated Alpha-Synuclein in Mild Cognitive Impairment
Objective: To quantify the deposition of cutaneous phosphorylated alpha-synuclein (P-SYN) and plasma P-Tau217 in patients with mild cognitive impairment (MCI) due to suspected Alzheimer’s disease…Synergistic Impact of Plasma Neurofilament Light Chain and Neuroimaging Deficits on Cognitive Decline in Prodromal Lewy Body Disease
Objective: To assess the synergy between neuroimaging deficits and plasma biomarkers in predicting longitudinal cognitive and motor progression in individuals at high risk for prodromal…Acrostic for the differential diagnosis of atypical Parkinsonian
Objective: Evaluating the usefulness of clinical acrostic for the differential diagnosis of atypical Parkinsonian syndromes Background: Differentiate Parkinson’s disease from atypical parkinsonian syndromes is challenging…Cross-Continental Differences in Prodromal Symptoms of Lewy Body Dementia: A Comparative Analysis Across Asia, Europe, and North America
Objective: To systematically analyze the prevalence of prodromal symptoms in Lewy Body Dementia (LBD) across different continents, focusing on REM sleep behavior disorder (RBD), hallucinations,…Safety and Feasibility of Repetitive Transcranial Magnetic Stimulation in Dementia with Lewy Bodies: An Ongoing Proof-of-Concept Study
Objective: To investigate the safety and potential cognitive benefits of repetitive transcranial magnetic stimulation (rTMS) in patients with dementia with Lewy bodies (DLB) using a…The predictive value of the 18F-FDG PET-derived Parkinson’s disease Related Pattern for neurodegenerative disease progression in isolated REM Sleep Behavior Disorder
Objective: To determine whether baseline and longitudinal Parkinson’s disease–related pattern expression predicts conversion to Parkinson’s disease or dementia with Lewy bodies in idiopathic REM sleep…Identification of Alpha-synuclein Pathology in Dementia with Lewy Body Participants by Seed Amplification Assay
Objective: To assess frequency and type of misfolded α-synuclein aggregates (syn-seeds) in cerebrospinal fluid (CSF) from dementia with Lewy bodies (DLB) participants by means of…
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