Latent Clinical States and Longitudinal Transitions in Prodromal Lewy Body Disease: A Data-Driven Analysis from the NaT-PROBE Study
Objective: To elucidate the structure of clinical heterogeneity and longitudinal transition patterns in a prodromal Lewy body disease (LBD) screening cohort using a data-driven approach.…Human Snca Knock-In Mouse as a Model for Synucleinopathy Research
Objective: Inter-species differences between mouse and human α-synuclein (asyn) may influence aggregation and pathology in animal models, highlighting the need for models expressing human asyn.…Emergence of Cortical Amyloid from the Prodromal Stage of the Lewy Body Disease Spectrum: Evidence from a PiB-PET Study
Objective: To characterize β-amyloid (Aβ) deposition across the Lewy body disease (LBD) spectrum using Pittsburgh compound B positron emission tomography (PiB-PET) and examine the influence…Progressive Dynamic Functional Network Disorganisation and its Association with Phenoconversion in Isolated REM Sleep Behaviour Disorder: A Multicentre Study
Objective: To characterise static and dynamic functional connectivity signatures of disease progression and phenoconversion in a multicentre longitudinal cohort of individuals with isolated REM sleep…Cholinergic Pathway Degeneration Predicts Differential Phenoconversion to Synucleinopathies in Idiopathic REM Sleep Behavior Disorder
Objective: This cross-sectional and longitudinal study aimed to elucidate the pattern of cholinergic white matter pathway degeneration underlying the phenoconversion trajectories in iRBD patients. Background:…Non-Rapid Eye Movement Sleep Neurophysiological Alterations in Lewy Body Disorders
Objective: To characterise NREM sleep neurophysiology across multiple domains in Lewy body disorders (LBDs) relative to healthy controls. Background: Sleep disturbances are highly prevalent in…Remote Longitudinal Follow-up of Participants in the Parkinson’s Progression Markers Initiative (PPMI)
Objective: To assess a personalized protocol focused on maintaining contact for long-term follow-up of current and former clinical research participants Background: PPMI-FOUND enrolls participants at…Prevalence and Clinical Determinants of Cognitive Impairment in a Diverse Parkinson’s Disease Cohort
Objective: To estimate the prevalence of cognitive impairment in a diverse Parkinson’s disease (PD) cohort and explore its associations with vascular, motor, and non-motor determinants.…A novel pro-drug overcomes short-half life and absorption challenges and increase brain penetration of dopamine as a potential therapy for Parkinson’s disease
Objective: We developed a new small molecule drug candidate that would increase the effectiveness of dopamine delivery to the brain. We also sought to mitigate…Cortical–Subcortical Structural Signature of dementia with lewy bodies Reveals Cognitive Trajectories of Lewy Body Disease in REM Sleep Behavior Disorder
Objective: We aimed to derive a DLB-related structural MRI pattern based on cortical and subcortical morphometry and investigate whether this pattern predicts phenoconversion and clinical…
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