Baseline and Longitudinal NSD-ISS Staging of the PPMI Cohort
Objective: To apply biological definition and Neuronal α-Synuclein Disease Integrated Staging System (NSD-ISS) to the PPMI baseline and longitudinal dataset. Background: The NSD-ISS Working Group…The Pro-LBD Study Investigating Early Detection, Prognosis, and Biomarkers of Prodromal Lewy Body Diseases
Objective: The Pro-LBD cohort study is a prospective, long-term, clinic-biological cohort study of participants who are stratified by their risk of developing a Lewy body…Prediction of amyloid positivity in Dementia with Lewy bodies using the early-phase 18F-FP-CIT PET images
Objective: This study aims to explore whether early-phase 18F-N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl) nortropane (18F-FP-CIT) positron emission tomography (PET) images can predict β-amyloid positivity on 18F-florbetaben (18F-FBB) PET scans…A case of progressive supranuclear palsy followed by dementia with Lewy bodies
Objective: We report a case of dementia with Lewy bodies (DLB) that was diagnosed one year after the diagnosis of PSP. Background: Progressive supranuclear palsy…18F-Florzolotau PET uncovers the Co-pathological Heterogeneity of Tau Protein in Dementia with Lewy Bodies
Objective: We attempted to reveal the topographical deposition patterns of tau proteins in the living brains of patients with DLB in vivo by virtue of…Blood-brain Barrier Breakdown in Dementia with Lewy Bodies
Objective: To explore the characteristics of BBB breakdown in DLB and find the correlation between leakage and cognitive domains. Background: These years, researchers found that…Free-water MRI Correlates of Pareidolia in Dementia with Lewy Bodies
Objective: To evaluate free-water (FW) differences in patients with dementia with Lewy bodies (DLB) with versus without pareidolias Background: Pareidolias are a type of illusion…Incident & Prevalent Dementia in Individuals with Parkinson’s Disease in the Framingham Heart Study
Objective: To examine incident and prevalent dementia cases in individuals with Parkinson's Disease (PD) within a longitudinal population-based study Background: Longitudinal studies have found that…Plasma pTau181 and pTau217 Detect Amyloid Co-pathology and Have Specific Cut-offs in Lewy Body Disease
Objective: We assess: 1) if the diagnostic accuracy of plasma pTau181 differs from pTau217 in detecting amyloidosis (Aβ) in people with Lewy body disease (LBD)…Aberrant connectivity in Resting-State Brain Networks Underlying Neuropsychiatric Symptoms in Prodromal Lewy Body Dementia.
Objective: This study aimed to determine the functional neural correlates of neuropsychiatric symptoms (NPS), including mood disorders, anxiety and psychosis, in prodromal Lewy body dementia (LBD)…
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