The Clinical and Neuropathological Factors Associated with Brain Atrophy in CSF1R-RD.
Objective: To characterize the clinical and neuropathological factors associated with brain atrophy in CSF1R-related disorder (CSF1R-RD). Background: CSF1R-RD is a rare, fatal autosomal dominant leukoencephalopathy…Raman Spectroscopic Identification of Biochemical Alterations in Post Mortem Brain Tissue Microarrays from Parkinsons and Alzheimers Disease
Objective: To investigate biochemical differences in neuronal, vascular and neuropil regions of post mortem brain tissue from Parkinsons disease and Alzheimers disease using Raman microscopy.…Predicting Dementia in Parkinson’s Disease Using Blood-Based Proteomics
Objective: To identify a proteomic profile associated with the future development of dementia in recently diagnosed Parkinson’s disease (PD) patients. Background: Dementia is a common…Strategies for Harmonising Clinical Data for Multi-Centre, Large Scale Genome-Wide Association Studies
Objective: To establish a data harmonisation framework for classifying cognitive status in Parkinson’s disease (PD) across multiple study and data types to facilitate large-scale genetic…Multivariate Cognitive Markers of Dementia Progression in Parkinson’s Disease
Objective: To identify neuropsychological markers at the PD-MCI stage associated with the progression severity to PDD using a multivariate, data-driven approach with longitudinal validation. Background:…Neuropsychiatric Symptoms in Lewy Body Disease: Monoaminergic Activity and Resting State Networks
Objective: Investigating how neuropsychiatric symptoms (NPS)—depression, anxiety, and apathy—relate to functional connectivity between monoaminergic nuclei and the limbic network (LN), default mode network (DMN), and…Machine Learning for Early Detection of Huntington’s Disease: Integrating Non-Motor Symptoms and Gender-Specific Differences
Objective: To develop a machine learning (ML) model for early Huntington’s disease (HD) detection by integrating non-motor symptoms (NMS) and DNA methylation patterns, leveraging gender-specific…Bidirectional associations between seizures and parkinsonism: a retrospective case series
Objective: Within a single center, describe individuals with parkinsonism who develop seizures and vice versa based on epilepsy and movement disorders evaluation. Background: While neurodegeneration…Atypical Phenotype of SORL1-Associated Early-Onset Alzheimer’s Disease With Oromandibular and Cervical Dystonia
Objective: We present a case of early-onset Alzheimer’s disease associated with a mutation in the SORL1 gene accompanied by extrapyramidal symptoms, including oromandibular and cervical…Social Network Structure and Caregiving Experiences in South Asian Families Living with Dementia Associated with Parkinsonian Disorders
Objective: To characterize social network structure and caregiving among SA families with Parkinsonian dementia (PD) and compare them with White American (WA) caregiving networks. Background:…
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