Specific SLC6A3 variant shows association with better memory in PD patients longitudinally
Objective: To study the effect of SLC6A3VNTR on PD patients’ cognition longitudinally. Background: Solute carrier family 6 neurotransmitter transporter dopamine member 3gene (SLC6A3) has two common…Carrier Mediated Delivery System Bearing Dopamine for Effective Management of Parkinsonism
Objective: In the present investigation, amino acid coupled liposomes bearing dopamine-HCl were prepared to deliver drug to the brain utilizing receptor-mediated transcytosis for effective management…The contribution of striatal dopamine to feedforward motor control during gait initiation in Parkinson’s disease
Objective: To establish the contribution of striatal dopamine to gait initiation in Parkinson’s disease. Background: Gait initiation (GI) is characterized by anticipatory postural adjustments (APAs),…Memory enhancing effect of Combined Alcoholic Extract of Cedrus deodara Loud. and Vitex Nirgundi in scopolamine-induced cognitive impairment in mice
Objective: Epidemiological studies of Indian population reveal that dementia is largely a hidden problem in India. Ayurveda claims several plants are beneficial in cognitive disorders.…Tissue Engineered Nigrostriatal Pathway as an Anatomically-Inspired Test-Bed for Evaluating Axonal Pathophysiology
Objective: We previously developed the first micro-tissue engineered nigrostriatal pathway encased in a tubular hydrogel with 3D structure, multicellular composition, and architecture of long axonal…Dielectric Properties of a Blood Plasma Predict Motor Deficits in a 6-Hydroxydopamine-Induced Rat Model of Parkinson’s Disease
Objective: This study presents a novel method of predicting the behavioral pattern in male Sprague-Dawley rats with motor deficits impairment, based on the measurement of…Glabellar tap predicts dopamine transporter deficiency in parkinsonism
Objective: The objective of this study was to investigate the association between glabellar tap findings with nigrostriatal dopamine function in patients with unclear parkinsonism. Background:…Comparison between [11C]PE2I PET and [123I]FP-CIT SPECT as markers of DAT expression in early Parkinson’s disease
Objective: To compare single-photon emission computed tomography (SPECT) with [123I]FP-CIT and positron emission tomography (PET) with [11C]PE2I as markers of dopamine transporter (DAT) loss in…Awareness of Levodopa/Carbidopa spacing with meals in patients of Idiopathic Parkinson’s disease – Insights from an Indian Parkinson’s Registry
Objective: Food interferes with gastrointestinal absorption of levodopa which requires spacing with meals. Study evaluated how many patient were spacing levodopa correctly, its effect on…Cognitive Inhibitory Control and Response to Dopaminergic Medication in Parkinson’s Disease
Objective: To investigate whether response to dopaminergic medication (DM) correlates to inhibitory cognitive control (IC) in patients with Parkinson's disease (PD). Background: In the MDS…
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