Comparison of DAT scan, cardiac MIBG scintigraphy, and cerebrospinal fluid 5HIAA levels in Parkinsonian syndrome
Objective: To assess the associations of presynaptic dopamine transporter (DAT scan), cardiac 123I-meta-iodobenzylguanidine (MIBG) scintigraphy, and cerebrospinal fluid (CSF) levels of 5-hydroxyindole acetic acid (5HIAA)…Role of dopamine and GABA during subthalamic and pallidal deep brain stimulation: Evidence of dopamine release during subthalamic Deep Brain Stimulation
Objective: We recorded the single-unit activity of striatal cholinergic interneurons of healthy monkeys during high-frequency stimulation (HFS) of the subthalamic nucleus (STN) and globus pallidus…Effect of dopamine and L-3,4 – dihydroxyphenylalanine in treatment of experimental parkinsonism
Objective: To study effect of dopamine and L-3,4 - dihydroxyphenylalanine in treatment of experimental parkinsonism. Background: Prospects of treatment of Parkinson's disease are also closely…Increasing placebo response in Parkinson’s disease through apomorphine pre-conditioning
Objective: To see whether a placebo response requires pharmacological pre-conditioning with apomorphine. Background: Placebos have been found to affect the patient's brain in a number…Differential expression of cerebral dopamine neurotrophic factor (CDNF) in the hippocampus and in the striatum of LRRK-2 mutant rat model of Parkinson’s disease
Objective: The objective of our study was to characterize the behavioral phenotype of the transgenic LRRK-2 rat in the context of PD model and to…Improving clinical detection of balance deficits in individuals with Parkinson’s disease with and without freezing of gait and the effects of dopaminergic replacement therapy
Objective: Since it has been argued that PD+FOG have greater sensory impairments compared to PD-FOG, the current study evaluated whether the modified Clinical Test of…The role of striatal dopaminergic terminals in early de novo PD patients with speech impairment
Objective: To assess the role of striatal dopaminergic terminals in early de novo (untreated) Parkinson's disease (PD) patients with impairment of speech. Background: Dopamine has…Optimization of 6-hydroxydopamine animal model of early stage Parkinson´s disease for the assessment of neurorestorative therapies
Objective: To optimize a simple unilateral partial 6-hydroxydopamine (6-OHDA) lesion protocol that would produce 40-60% striatal dopamine (DA) depletion with detectable motor deficits and to…Reward insensitivity differentiates apathy from depression in Parkinson’s disease
Objective: To determine if a potential cause of apathy in Parkinson's disease (PD) might be insensitivity to rewards, establish if this differentiates apathy from depression…Visual vs. automated analysis of [123I]FP-CIT SPECT scans in patients with parkinsonism
Objective: To investigate the differences between visual and automated analyses of brain dopamine transporter (DAT) SPECT scans. Background: Clinical evaluation of DAT SPECT scans typically…