Non-motor signs in essential tremor and essential tremor-plus syndromes
Objective: To investigate the non-motor profiles of essential tremor (ET) and essential tremor-plus (ET-plus) syndromes. Background: The recently established concept of differentiating ET from ET-plus…A Phase 2 Randomized, Double-blind, Placebo-controlled Trial of PRAX-944 for the Treatment of Essential Tremor
Objective: Evaluate the tolerability, safety and efficacy of PRAX-944, a selective small molecule T-type calcium channel blocker, for treatment of essential tremor (ET). Background: Essential…Neurofilament light chain protein (NfL) is elevated in Essential Tremor
Objective: To investigate neurofilament light chain protein (sNfL) concentrations in serum in Essential Tremor (ET) compared to healthy controls and to assess whether sNfL is…Bilateral Magnetic Resonance Imaging-Guided Focused Ultrasound Thalamotomy in Medication-Resistant Essential Tremor Treatment.
Objective: To assess the efficacy and safety of bilateral magnetic resonance imaging-guided focused ultrasound thalamothomy for medication refractory essential tremor in prospective observation of two…Distinct Patterns of Tremor Network Microstructure for Essential Tremor and Parkinson’s Disease
Objective: We aimed to identify differential patterns of aberrant tremor network microstructure using DSI among the following groups: (1) ET, (2) PD, and (3) healthy…Acute Stimulation-Induced Ataxia From Thalamic Deep Brain Stimulation
Objective: To characterize stimulation-induced ataxia in Essential Tremor patients treated with VIM DBS. Background: In Essential tremor (ET) patients with medically refractory tremor, deep brain…A phase 2b, randomized, dose-response study of SAGE-324/BIIB124 for the treatment of essential tremor: KINETIC 2 trial in progress
Objective: The phase 2b KINETIC 2 trial is a double-blind, randomized, placebo-controlled, dose-response study designed to evaluate SAGE-324/BIIB124 (SAGE-324) for the treatment of patients with…Electrical stimulation of muscle afferents for tremor reduction in essential tremor patients
Objective: To describe the preliminary clinical results of a research project on electrical stimulation of muscle afferents to reduce tremor in patients with Essential Tremor…The Hidden Disease Burden and Treatment Experience of Patients with Essential Tremor: A Retrospective US Claims Analysis
Objective: To describe the attributes of patients with essential tremor (ET), associated comorbidities, and ET treatments using a US claims database. Background: ET is estimated…Fall prevention in patients undergoing Magnetic resonance-guided focused ultrasound thalamotomy (MRgFUS thalamotomy) for refractory essential tremor (ET)
Objective: To assess the efficacy of physiotherapy with fall prevention instructions in patients with refractory ET who underwent unilateral MRgFUS thalamotomy. Background: unilateral MRgFUS thalamotomy…
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