Cholinergic basal forebrain and hippocampal structure influence visuospatial function in Parkinson’s disease
Objective: To assess relationships between the structural status of the cholinergic basal forebrain (cBF), hippocampus (HPC) and multi-domain cognitive function in Parkinson’s disease (PD). Background:…Microglial activation, white matter and hippocampal damage correlate with cognitive impairment in chronic cerebral hypoperfused and MPTP-lesioned mice
Objective: We hypothesize that cerebral hypoperfusion may influence the cognitive function of PD animal models. To investigate the effects of cerebral hypoperfusion and microangiopathy on…Increased hippocampal activation in Parkinson’s disease related amnestic mild cognitive impairment
Objective: To assess the functional significance of hippocampal network dysfunction in Parkinson’s disease related amnestic mild cognitive impairment (PD aMCI) using high-resolution functional neuroimaging. Background:…Physical and cognitive stimulation through environmental enrichment prevents early molecular pathology in a Parkinson´s disease model
Objective: Understand the molecular principles and identify genetic drivers underlying and mitigating the preventative effects of environmental enrichment on the unfolding of Parkinson´s disease (PD) pathology.…Differential expression of cerebral dopamine neurotrophic factor (CDNF) in the hippocampus and in the striatum of LRRK-2 mutant rat model of Parkinson’s disease
Objective: The objective of our study was to characterize the behavioral phenotype of the transgenic LRRK-2 rat in the context of PD model and to…Impaired hippocampal neurogenesis associates with serotonergic axonal degeneration in transgenic rat and mouse models of Parkinson’s disease
Objective: To evaluate the impact of α-synuclein accumulation on the hippocampal serotonergic system and hippocampal plasticity in two different α-synuclein expressing rodent models. Background: Parkinson's…