Impact of Alpha-Synuclein Burden and Cellular Stress on GBA-PD Macrophage
Objective: This study explores how non-neuronal dysfunction drives the rapid progression of GBA-PD, aiming to identify therapeutic targets that restore protein degradation and cellular stability.…Peripheral Inflammatory Markers and Clinical Correlations in Parkinson’s Disease Patients Carrying LRRK2 G2385R and R1628P Variants
Objective: To investigate plasma cytokines and chemokines with clinical correlations between Parkinson’s disease (PD) patients carrying LRRK2 p.G2385R and/or p.R1628P variants, idiopathic PD (iPD), and healthy controls.…Neuroprotective Effects of Emodin Against Rotenone-Induced Parkinsonism Through Regulation of SIRT1-Mediated Inflammasome and Nrf2 Pathways
Objective: This study aimed to investigate the neuroprotective potential of emodin in a rotenone-induced PD model and to elucidate its underlying molecular mechanisms focusing on…Title: Association of Neurofilament Light Chain and Peripheral Inflammatory Biomarkers with Clinical Progression in Parkinson’s Disease
Objective: To investigate the correlation between serum NfL levels, selected peripheral inflammatory biomarkers, and clinical measures of disease severity and progression in patients with Parkinson’s…Deciphering the NLRP3-Driven Olfactory–Brain Axis in Parkinson’s disease: Neuroprotective Role of Betulin
Objective: The present study aimed to elucidate the molecular mechanism underlying bidirectional olfactory–brain dysfunction mediated through NLRP3 inflammasome activation in cellular models of PD and…Interleukin 6 in the assessment of Parkinson’s disease and Progressive Supranuclear Palsy
Objective: The aim of this research is to analyze the relevance of serum interleukin 6 levels in the evaluation of Parkinson’s disease (PD) and Progressive…Astrocyte Derived Extracellular Vesicle miR 210 Expression in Exenatide Treated Patients with Parkinson’s Disease
Objective: To investigate miR‑210 expression in astrocyte‑derived extracellular vesicles (ADEVs) from individuals with PD treated with Exenatide versus placebo. Background: Hypoxic stress profoundly alters neuronal…Phase 1 Study of BT-409, a potent, selective, brain-penetrant, and oral small molecule inhibitor of NLRP3 in Healthy Volunteers and Adults with Parkinson’s disease
Objective: The objective of the study is to evaluate the safety, tolerability, and pharmacokinetics of BT-409. Background: Chronic activation of innate immune pathways has emerged…Clinical Relevance of Oral Health Assessment in Parkinson’s Disease Monitoring
Objective: To evaluate the clinical relevance of oral health assessment in Parkinson’s disease (PD) by determining whether oral inflammatory, microbial, and periodontal alterations are associated…Stage-Dependent Dysregulation of Peripheral TREM2, SOD1, and Neurofilament Light Chain Across the Parkinson’s Disease Continuum
Objective: To evaluate plasma and PBMC biomarkers of neurodegeneration, neuroinflammation, microglial activation, and oxidative stress across clinically defined stages of Parkinson's disease (PD). Background: PD…
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