Listen to the heart: Do loud vagal rhythms disharmonize the autonomic symphony in Parkinson’s disease patients with the LRRK2 mutation?
Objective: Assessment of cardiac autonomic function through standard and novel features of heart rate variability (HRV) in individuals who carry the G2019S mutation in the…Evaluation of the relationship between Leucine-rich repeat kinase 2 (LRRK2) S1647T variants and smoking with risk of Parkinson’s Disease in the Singapore population
Objective: To investigate whether cigarette smoking influences the relationship between S1647T variants and risk of PD in the Singapore population. Background: Case-control studies in southern…Objective and quantifiable assessment of sleep in patients with Parkinson’s disease using a wearable sensor
Objective: To explore the feasibility of using a body-fixed sensor (BFS) to assess sleep disturbances in patients with Parkinson's disease (PD), carriers and non-carriers of…Resistance to Parkinson’s disease among LRRK2 mutation carriers is associated with higher plasma levels of urate but not its purine precursors
Objective: To determine whether plasma purine concentrations differ between people with Parkinson's disease (PD) and matched controls among carriers of pathogenic mutations in Leucine-Rich Repeat…Validation of protein phosphatases that regulate the LRRK2 phosphorylation cycle
Objective: To identify and validate candidate phosphatases regulating the LRRK2 phosphorylation cycle. Background: Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) are one…Comparison of thermal sensation and pain thresholds in LRRK2 carriers and non carriers with Parkinson’s disease
Objective: To compare between clinical findings and quantitative sensory testing (QST) data in patients with Parkinson's disease (PD) positive and negative for mutations in LRKK2.…Molecular Genetics and Functional Studies of LRRK2 Gene Variations in Parkinson’s Disease
Objective: To evaluate the function role of ROC domain in the brains of LRRK2 transgenic mice model and normal control mice. Background: Mutations in leucine-rich…PD associated with GBA and LRRK2 mutations: Genotype-phenotype correlation
Objective: To study differences in disease characteristics in PD associated with 1 or 2 mutations in the most common PD-associated genes in the Ashkenazi Jewish…Activation of chaperone-mediated autophagy reduces oligomeric alpha-synuclein accumulation in LRRK2(R1441G) knockin mouse model of Parkinson’s disease (PD)
Objective: To determine age-dependent accumulation of oligomeric alpha-synuclein in the brain of aged LRRK2(R1441G) knockin mice; and to explore whether activation of chaperone-mediated autophagy (CMA)…Application of the Movement Disorder Society Prodromal Criteria in healthy G2019S-LRRK2 carriers
Objective: To evaluate the MDS prodromal criteria in first-degree relatives of Ashkenazi Jewish G2019S-LRRK2 PD patients, who are considered a population at risk for developing…
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