Brain-targeted dual-loaded extracellular vesicles enable PROTAC-mediated LRRK2 degradation in Parkinson’s disease
Objective: To develop a brain-targeted extracellular vesicle (EV) platform capable of delivering proteolysis-targeting chimeras (PROTACs) across the BBB and inducing degradation of pathogenic proteins in…Responsiveness of Sensor-Derived Measures From a Smartphone-Based Active Typing Test in the Phase 2b LUMA Study of Parkinson’s Disease
Objective: Investigate the measurement properties of exploratory sensor-derived measures (SDMs) from a smartphone-based typing test in the LUMA study of BIIB122/DNL151 for Parkinson’s disease (PD).…Responsiveness of a Smartphone-Based Sensor-Derived Composite Endpoint in a Phase 2b Study in Parkinson’s Disease (PD)
Objective: Development of a sensor-derived composite score (CS) for progression of motor symptoms in the LUMA study in PD. Background: LUMA (NCT05348785) is a randomized Phase 2b…Unraveling Kinase-Phosphatase Dysregulation in Parkinson’s disease Peripheral Blood Mononuclear Cells Through Targeted Transcript Analysis
Objective: To probe kinase-phosphatase dysregulation and peripheral biomarker potential in peripheral blood mononuclear cells (PBMCs) via LRRK2 (kinase), PPM1H and PP2A (phosphatases), LC3 (autophagy), and…LRRK2 in Focus: A Global Browser Linking Genetic Diversity to Functional Effects
Objective: To develop a publicly accessible web browser that allows users to easily explore the distribution of LRRK2 variants in both Parkinson’s disease (PD) and…Comparative Motor Response to Bilateral STN‑DBS in LRRK2‑Related and Idiopathic Parkinson’s Disease
Objective: To compare motor improvement after subthalamic nucleus deep brain stimulation (STN‑DBS) in patients with LRRK2‑associated Parkinson’s disease (PD) versus idiopathic PD (iPD). Background: LRRK2…Interplay of sex and GBA1 and LRRK2 genotype in Parkinson disease progression
Objective: To characterize disease heterogeneity and how sex impacts motor and cognitive progression class membership across genetic subgroups of GBA1, LRRK2, and idiopathic Parkinson disease (PD). Background: Autosomal…Monocyte and T-cell Immunological Profiles of Asian LRRK2 Variants G2385R And R1628P in Parkinson’s Disease: Associations with Clinical Measures
Objective: To evaluate the clinical correlates of monocyte and T-cell immunoprofiles in Parkinson’s disease (PD) with and without Asian LRRK2 variants. Background: Immune dysregulation has…Genomic Insights into Parkinson’s Disease: LARGE-PD and PD GENEration Collaboration in El Salvador
Objective: To characterize clinical and genetic features of Parkinson’s disease (PD) in El Salvador in the PD GENEration and LARGE-PD. Background: Central American populations remain…Urine and Plasma Bis(monoacylglycero)phosphate (BMP) in Asian LRRK2 p.G2385R and p.R1628P Variant Carriers with Parkinson’s Disease
Objective: To compare urine and plasma bis(monoacylglycero)phosphate (BMP) levels in Parkinson disease (PD) patients carrying Asian-prevalent LRRK2 variants (p.G2385R, p.R1628P) against idiopathic PD (iPD) and…
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