MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

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Articles tagged "Leucine-rich repeat kinase 2(LRRK2)"

  • 2024 International Congress

    Dysregulated Anti-Viral Response in LRRK2 Mice Following Infection with H1N1 Influenza Induces DA Neuron Loss in the SNpc.

    K. Crowther, R. Smeyne, E. Kozina (Philadelphia, USA)

    Objective: In this study, we sought to determine if there is a synergistic effect of non-neurotropic H1N1 influenza and the G2019S LRRK2 mutation associated Parkinson’s…
  • 2024 International Congress

    Sleep Characteristics in Idiopathic and Genetic Parkinson’s Disease

    A. Astefanous, M. Yang, D. Raymond, M. Rawal, J. Liang, A. Cohen, N. Becker, B. Plitnick, A. Yoo, V. Katsnelson, K. Leaver, S. Bressman, M. Figueiro, R. Saunders-Pullman, A. Wise (NEW YORK, USA)

    Objective: To investigate sleep features among individuals with genetic subgroups of PD, including LRRK2 G2019S-PD, GBA-PD, and iPD (idiopathic PD with no known genetic variant). Background:…
  • 2024 International Congress

    LRRK2 G2019S mutant damages mitochondrial transfer by a Drp1-STX17 depend pathway in Parkinson’s disease

    X. Cheng (Suzhou, China)

    Objective: We focus on the novel endogenous neural repair function that comes from the mitochondrial transfer, and we aim to elucidate the molecular mechanism by…
  • 2024 International Congress

    Frequency of LRRK2 p.L1795F variant in Parkinson’s Disease patients from Central Europe within the CEGEMOD consortium

    M. Ostrozovicova, G. Tamas, K. Soos, P. Dusek, M. Grofik, V. Han, P. Holly, R. Jech, P. Klivenyi, N. Kovacs, K. Kulcsarova, E. Kurca, A. Lackova, J. Necpal, D. Pinter, E. Ruzicka, T. Serranova, K. Smilowska, I. Straka, T. Svorenova, P. Valkovic, K. Zarubova, H. Houlden, M. Rizig, M. Skorvanek (Kosice, Slovakia)

    Objective: The aim of this study was to investigate the presence of LRRK2 p.L1795F variant in PD patients from Central Europe. Background: Pathogenic variants in…
  • 2024 International Congress

    The role of LRRK2 in regulating microglial activity in Parkinson’s disease

    S. Brooker, A. Thomas, D. Krainc (Chicago, USA)

    Objective: To investigate the effects of pathogenic LRRK2 mutations on lysosomal function and phagocytic activity of microglia. Background: The LRRK2 G2019S mutation is one of…
  • 2024 International Congress

    Screening for newly PD-associated RAB32 p.S71R variant in Latin America

    M. Rivera Paz, E. Waldo, T. Leal, P. Reyes-Pérez, M. Inca-Martinez, S. Alcauter, I. Amorín, M. Cornejo-Olivas, E. Dieguez, I. Estrada-Bellmann, A. Hernández-Medrano, M. Jimenez-Del-Rio, A. Lescano, B. Muñoz Ospina, K. Nuytemans, J. Orozco, V. Raggio, M. Rentería, J. Rios-Pinto, M. Rodriguez-Violante, K. Salinas Barboza, A. Schuh, C. Velez-Pardo, I. Mata (Cleveland, USA)

    Objective: Our aim was to identify whether a novel putative pathogenic variant in RAB32, a gene recently associated with familial forms of Parkinson’s Disease (PD),…
  • 2024 International Congress

    Rationale for LRRK2 inhibition in sporadic Parkinson’s disease and the LUMA trial

    R. Hauser, A. Lang, L. Kalia, JT. Greenamyre, R. Llorens-Arenas, D. Jennings, B. Hersh, K. Fraser, S. Huntwork-Rodriguez, A. Henry, J. Kluss, C. Paisán-Ruiz, Z. Berger (Tampa, USA)

    Objective: To summarize the rationale for LRRK2 inhibition in sporadic PD patients without LRRK2 mutations, and to describe the current design of the LUMA study,…
  • 2024 International Congress

    LRRK2 Gene Mutation in Parkinson’s Disease

    A. Abbes, M. Mhiri, R. Ben Dhia, N. Gouta, M. Frih Ayed (Monastir, Tunisia)

    Objective: We aim to describe the clinical characteristics of PD linked to an LRRK2 mutation. Background: One of the most common monogenic forms of Parkinson's…
  • 2024 International Congress

    LRRK2-Associated Parkinsonism With and Without In Vivo Evidence of Pathologic Alpha-Synuclein: Clinical and Biomarker Characterization

    L. Chahine, D. Lafontant, C. Choi, H. Iwaki, M. Brumm, R. Alcalay, K. Nudelman, A. Dagher, K. Merchant, A. Vo, Q. Tao, C. Venuto, K. Kieburtz, K. Poston, S. Bressman, P. Gonzalez Latapi, B. Avants, C. Coffey, D. Jennings, E. Tolosa, A. Siderowf, K. Marek, T. Simuni (Pittsburgh, USA)

    Objective: To compare clinical and biomarker features and rate of progression among LRRK2-associated parkinsonism cases with and without in vivo evidence of pathologic alpha-synuclein (asyn)…
  • 2024 International Congress

    LRRK2 I1371V Mutation: Unraveling Pathogenic Mechanisms in Dopaminergic Neurons via Membrane Fluidity & Calcium Dysregulation using PD Patient iPSCs

    I. Datta, S. Jagtap, V. Holla, N. Kamble, R. Yadav, P. Pal (Bengaluru, India)

    Objective: To estimate pathogenicity of LRRK2 I1371V mutation in PD patient iPSC-derived DA-neurons & assess underlying disease mechanisms involving membrane fluidity, Ca2+ dysregulation, & Rab8A/Rab10…
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