Deep brain stimulation in Parkinson’s disease
Objective: Study the various clinical, electrophysiological and therapeutic parameters of operated patients. Evaluate the effectiveness of deep brain stimulation of STN in Parkinson's disease. Background:…Validation of a real- time monitoring system to detect motor symptoms in patients with Parkinson´s disease treated with Levodopa Carbidopa Intestinal Gel
Objective: Our aim was to analyze the ability of system to combine information on OFF periods, falls and dyskinesias of patients with PD. Background: Levodopa…A retrospective review of clinical and MRI/CT radiological correlation in progressive supranuclear palsy (PSP)
Objective: To investigate the clinical and MRI/CT radiological correlation to improve the diagnosis and management of PSP Background: PSP is a rare progressive neurodegenerative disease…Effect of dopaminergic treatment on digital sensor features in Phase II PASADENA Part 1 in early Parkinson’s disease
Objective: To characterize the sensitivity of smartphone and -watch sensor features to levodopa and dopamine agonist (DA-Tx) treatment. Background: Digital health technology tools (DHTTs) enable…Comparison of Antiparkinsonian Medication Initiation and Levodopa-Equivalent Daily Dose Across PPMI, STEADY-PD III, and SURE-PD3
Objective: To compare use of antiparkinsonian medications (APM) among early Parkinson disease (PD) patients across clinical study cohorts. Background: Initiation of APM is a key…Time to diagnosis of clinically established Parkinson’s disease or atypical parkinsonism: is a 5-year follow-up period necessary?
Objective: To determine the time frame to the diagnosis of clinically established Parkinson’s disease (PD) or atypical parkinsonism after an acute levodopa challenge (LDC) for…Early versus later levodopa and onset of motor fluctuations in PD: Observations from the Parkinson’s Outcomes Project
Objective: To characterize patients with early versus later levodopa exposure, defining “early” as within 2 years of Parkinson’s disease (PD) diagnosis, and to determine whether…Risk factors for the onset of dyskinesia in patients with Parkinson’s disease exhibiting wearing-off phenomena: A 1-year observational study in Japan (J-FIRST)
Objective: To investigate the risk factors for the onset of dyskinesia in patients with Parkinson's disease (PD) exhibiting wearing-off phenomena. Background: Dyskinesia occurs during long-term…Determination of the motor status after the implementation Levodopa-carbidopa intestinal gel in patients with advanced Parkinson’s disease using a Machine learning Algorithm
Objective: Aim of this study was to develop a random forest (RF)-based PD model to determine the postoperative motor outcome at 2 years follow-up after…Determination of 5-HT3 receptor levels with [3H]-GR 65630 binding in hemi-parkinsonian rats with L-DOPA induced dyskinesia
Objective: To determine the distribution of serotonin type 3 (5-HT3) receptors in brain areas implicated in L-3,4-dihydroxyphenylalanine (L-DOPA) induced dyskinesia in the 6-hydroxydopamine (6-OHDA)-lesioned rat…
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