A metabolomic signature of treated and drug-naïve patients with Parkinson disease: A pilot study
Objective: The aim of our case–control study is to compare entire blood metabolomic profiles obtained from treated PD patients, de novo PD patients and controls,…Serum cholesterol levels over time and risk of Parkinson’s disease
Objective: To evaluate the association of serum cholesterol levels over time with the risk of Parkinson's disease (PD); among statin-free individuals. Background: High levels of…Neuroactive steroids reverse the dopaminergic neurotransmission defectiveness in chronic hepatic (HE) encephalopathy: a possible involvement in HE related parkinsonism
Objective: In the present study, we describe the changes of the dopaminergic system occurring in the cirrhotic rats and concomitantly we investigated the effect of…Investigating the Lipidomic Signature of Spinocerebellar Ataxia (SCA1) Using A Liquid-Microjunction Surface Sampling Probe
Objective: Lipidomic analysis of mice with spinocerebellar ataxia by mass spectrometry. Background: Ataxia is a movement disorder affecting balance and coordination of limbs, gait, eyes…Alterations in lipid metabolism modify GBA1-mediated neurodegeneration in a Drosophila model of Parkinson’s disease
Objective: To understand how glucocerebrosidase (GBA1) mutations increase susceptibility to Parkinson's disease (PD). Background: Our understanding of the pathogenesis PD remains limited, and currently no…Elevated GM3 Plasma Concentration in Idiopathic Parkinson’s Disease: a Lipidomics Analysis
Objective: To test the association between plasma lipids and Parkinson disease (PD) diagnosis. Background: PD is a common neurodegenerative disease whose pathological hallmark is the…Plasma ceramides and glucosylceramides predict cognitive decline among cognitively normal Parkinson’s disease patients
Objective: To determine whether plasma ceramides, glucosylceramides, and their ratios predict cognitive decline among cognitively normal Parkinson's disease (PD) patients. Background: There are no biomarkers…Adult onset Niemann-Pick type C: 24 month follow-up on miglustat
Objective: To present a rare case of adult onset NPC patient and pointing out varying response of her distinct symptoms on long term follow up…Biochemical features of lipids spectrum in blood in patients with Parkinson’s disease
Objective: To study characteristic of lipid levels in patients with PD. Background: Currently, there is no clear data about the features of lipid metabolism in…Mitochondrial cardiolipin couples electron transport between ubiquinone and complex I to rescue PINK1 deficiency
Objective: Test the effect of loss of FASN on Pink1 deficiency. Background: PINK1 deficiency causes Parkinson's disease that is based on mitochondrial defects including inefficient…
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