Falls and frailty predicate escalating care needs in Parkinson’s disease
Objective: Assess the prevalence of falls in Parkinson's disease and evaluate change in care needs and institutionalisation in this cohort over a 5 year follow-up…The association between objectively measured physical activity and health-related-quality of life in people with Parkinson’s disease
Objective: To evaluate the association between a large number of objectively measured parameters of physical activity in the domestic environment using wearable sensors and Health-Related-Quality…LSVT-BIG© case studies: A snapshot of observations
Objective: This case presentation will outline two clients treated with LSVT –BIG and share some observations of the technique. Background: It is estimated that seven…Twelve-week sensor assessment in Parkinson’s disease: Impact on quality of life
Objective: To evaluate the effects of using wearables over a long time period on Health-Related Quality of Life (HRQoL) in Parkinson's disease (PD) patients. Background:…Therapeutic protocol for Parkinson’s patient with freezing based on action observation plus sonification: Preliminary results
Objective: To evaluate the effects of a novel experimental protocol to treat patients with Parkinson's disease (PwP) and freezing of gait (FoG), using functional, and…Quantification of postural stability in Parkinson’s disease patients utilizing mobile technology
Objective: To validate the use of a mobile device and an associated biomechanical outcome to objectively quantify postural stability in Parkinson's disease (PD) patients. Background:…A novel C. elegans model for identification of small molecules that target alpha-synuclein-mediated toxicity
Objective: To develop a novel transgenic C. elegans model to study dopaminergic neurodegeneration mediated by alpha-synuclein. Background: Targeting alpha-synuclein could be a disease-modifying strategy for…Neural mechanisms underlying step initiation failure in patients with Parkinson’s disease and freezing of gait
Objective: To investigate the neural mechanisms underlying gait initiation failure in Parkinson's disease patients with Freezing of Gait. Background: Freezing of Gait (FOG) is a…Modulation of local field potentials during gait in the STN of patients with Parkinson’s disease
Objective: PD patients with implanted DBS electrodes allow for the investigation of basal ganglia activity during gait. Background: Whereas the overall spectral content of local…Optogenetic silencing of locus coeruleus activity in mice impairs cognitive flexibility in an attentional set-shifting task
Objective: In this study we used unilateral optogenetic silencing of the LC in an attentional set-shifting task (ASST) to evaluate the influence of the LC…
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