Twelve-week sensor assessment in Parkinson’s disease: Impact on quality of life
Objective: To evaluate the effects of using wearables over a long time period on Health-Related Quality of Life (HRQoL) in Parkinson's disease (PD) patients. Background:…Therapeutic protocol for Parkinson’s patient with freezing based on action observation plus sonification: Preliminary results
Objective: To evaluate the effects of a novel experimental protocol to treat patients with Parkinson's disease (PwP) and freezing of gait (FoG), using functional, and…Quantification of postural stability in Parkinson’s disease patients utilizing mobile technology
Objective: To validate the use of a mobile device and an associated biomechanical outcome to objectively quantify postural stability in Parkinson's disease (PD) patients. Background:…A novel C. elegans model for identification of small molecules that target alpha-synuclein-mediated toxicity
Objective: To develop a novel transgenic C. elegans model to study dopaminergic neurodegeneration mediated by alpha-synuclein. Background: Targeting alpha-synuclein could be a disease-modifying strategy for…Neural mechanisms underlying step initiation failure in patients with Parkinson’s disease and freezing of gait
Objective: To investigate the neural mechanisms underlying gait initiation failure in Parkinson's disease patients with Freezing of Gait. Background: Freezing of Gait (FOG) is a…Modulation of local field potentials during gait in the STN of patients with Parkinson’s disease
Objective: PD patients with implanted DBS electrodes allow for the investigation of basal ganglia activity during gait. Background: Whereas the overall spectral content of local…Optogenetic silencing of locus coeruleus activity in mice impairs cognitive flexibility in an attentional set-shifting task
Objective: In this study we used unilateral optogenetic silencing of the LC in an attentional set-shifting task (ASST) to evaluate the influence of the LC…The interactive walkway: Towards assessing gait-environment interactions in a clinical setting
Objective: To determine the usability of the Interactive Walkway (IWW) for the assessment of walking adaptability. Background: A prerequisite for safe walking is one's ability…A step forward to the future: UPDRS kinematic measures for telemedicine
Objective: We set up an experimental instrumentation to quantify selected items of UPDRS by a Kinect technology and body sensory-network (BSN), destinated to an easy…A rapid chemical-genetic screen utilising impaired movement phenotypes in caenorhabditis elegans
Objective: Development of a fast and unbiased screening method to identify C. elegans mutants with movement disabilities and drugs to improve impaired locomotion. Background: Identifying…
