Boosting Clinical Trial Power in Parkinson’s Disease with AI-Generated Digital Twins
Objective: To evaluate the incorporation of prognostic digital twins to enhance traditional clinical trials in Parkinson’s Disease (PD) for disease modifying therapies. We assess the…Three-Year Progression of the Postural Control Alterations in Hereditary Spastic Paraplegias
Objective: To assess the progression of postural control impairments in patients with HSP and identify the most sensitive COP parameter to change during a three-year…Long-Term Evolution of Advanced Parkinson’s Disease Burden: Subgroup Analysis from the 24 Month International PROSPECT Observational Study
Objective: To evaluate the long-term evolution of clinical outcomes and treatment patterns in people with advanced Parkinson’s disease (PwaPD) whose symptoms are inadequately controlled by…Association of Liver Fibrosis with Motor Deficits in Parkinson’s Disease
Objective: To determine the impact of liver fibrosis on motor symptoms in Parkinson’s disease Background: Parkinson’s disease motor symptoms can vary with systemic illnesses [1,2].…Body Mass Index as a Possible Poor Prognostic Factor in Motor and Postural Condition Through the Evaluation of MDS-UPDRS 3.3 – 3.18 in Patients with Parkinson’s.
Objective: To determine the degree of motor and postural impairment of patients with Parkinson's Disease at the time of their first consultation according to the…Parkinson Patients` Motor and Cognitive Functions are Improved by High Intensity LSVT®BIG Physiotherapy – a Randomized Prospective Pilot Trial
Objective: The objective of this pilot study was to evaluate the potential efficacy of high intensity physiotherapy LSVT®BIG on motor and non-motor functions of PD…Non-invasive transcranial Eectrical Stimulation (tRNS and tACS) targeting the Pallidum in normal Controls and PD Patients by rotating electrical Fields
Objective: To identify if low intensity transcranial electric stimulation targeting the pallidum influences motor cortex excitability. Background: Low intensity electrical stimulation has been shown to…Comparison of Composite Method Calculations for Monitoring Disease Progression in Early Parkinson’s Disease
Objective: Objective: To evaluate the influence of composite scoring methodologies using digital measures of gait, tremor, and bradykinesia to monitor disease progression over one year…Efficacy of Novel A2A/A1 Antagonist in Motor and non-Motor Symptoms of MPTP-Treated Macaques
Objective: Our primary objective was to test the novel adenosine A2A/A1 receptor antagonist IDAA-338 in alleviating Parkinsonian symptoms when given as a mono or as…Temporal coordination of head and trunk during 360-degree turning in Parkinson’s Disease
Objective: The purpose of this study is to investigate different strategies of temporal coordination of the head and trunk in people with Parkinson's disease(PD) while…
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